Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension.

Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Research Abstract Details 

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Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Abstract Text:

Bindu Chamarthi,Nikheel S Kolatkar,Steven C Hunt,Jonathan S Williams,Ellen W Seely,Nancy J Brown,Laine J Murphey,Xavier Jeunemaitre,Gordon H Williams,

CONTEXT: Emerging evidence suggests a role for cortisol in essential hypertension, and preliminary reports indicate that urinary free cortisol (UFC) may be an intermediate phenotype. OBJECTIVES: The objectives of this study were: 1) confirm bimodality of UFC, 2) assess whether UFC variations aggregate in hypertensive families, and 3) compare low-mode and high-mode UFC groups for distinguishing features. SUBJECTS/SETTING: Subjects included 390 hypertensives and 166 normotensives from the general community. DESIGN/INTERVENTIONS: Subjects had blood pressure and laboratory measurements on high- and low-salt diets. Familial aggregation was evaluated in 250 hypertensive siblings from 117 families. RESULTS: Hypertensives had higher UFC than normotensives (P<0.001) and bimodal distribution of UFC (P<0.0001). Analyses were controlled for gender and dietary sodium, which are confounding determinants of UFC. Mean low-mode UFC (33.8+/-10.6 microg per 24 h) was similar to that of normotensives. The high mode, comprising 31.3% of hypertensives, had less change in mean arterial pressure between diets than the low mode (P=0.01) without any other significant differences. Observed proportions of concordance and discordance for UFC mode differed significantly from that expected (P<0.001). Observed concordance for the high mode was twice that expected, whereas for the low mode, it was similar to that expected by chance. Family membership explained a significant proportion of variance in UFC classification (P=0.027). UFC mode of one sibling was a significant predictor of the UFC mode of the other sibling [odds ratio 6.6, 95% confidence interval (2.4-18.0), P<0.001]. CONCLUSION: High-mode UFC is an intermediate phenotype of hypertension associated with salt resistance and a strong familial component supporting heritability.

Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Publishing Authors By Initials

B Chamarthi,NS Kolatkar,SC Hunt,JS Williams,EW Seely,NJ Brown,LJ Murphey,X Jeunemaitre,GH Williams,

For similar inorganic chemicals: sodium compounds: sodium, dietary research abstracts see: inorganic chemicals: sodium compounds: sodium, dietary research

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Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 1340-6

Journal Abbreviation:

ISSN: 0021-972X

DAY: 30

MONTH: 01

YEAR: 2007

Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Keywords Mesh Terms:

KEYWORDS: Sodium, Dietary

MESH TERMS: urine

Chemical & Substance for Abstract: Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension. Information

Substance Name: Hydrocortisone

Registry Number: 50-23-7

Grant and Affiliation Information for Urinary free cortisol: an intermediate phenotype and a potential genetic marker for a salt-resistant subset of essential hypertension.

AFFILIATION: Division of Endocrinology, Diabetes, and Hypertension, Brigham and Women's Hospital and Harvard Medical School, 221 Longwood Avenue, Boston, Massachusetts 02115, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: T32HL007609

ACRONYM: HL

MEDLINETA: J Clin Endocrinol Metab

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