Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure.

Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Research Abstract Details 

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Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Abstract Text:

Kazuharu Ienaga,Ko Nakamura,Tomoe Fujisawa,Yasutsugu Fukunaga,Hiroshi Nihei,Mitsuharu Narita,Yasuhiko Tomino,Tsutomu Sanaka,Kazumasa Aoyagi,Koji Nakano,Hikaru Koide,Kazuharu Ienaga,Ko Nakamura,Tomoe Fujisawa,Yasutsugu Fukunaga,Hiroshi Nihei,Mitsuharu Narita,Yasuhiko Tomino,Tsutomu Sanaka,Kazumasa Aoyagi,Koji Nakano,Hikaru Koide,

Creatol (CTL) is a hydroxyl radical adduct of creatinine (Cr). The serum methylguanidine (MG) level and the MG/Cr molar ratio are reported to be biomarkers for oxidative stress. The aim of this study was to examine whether urinary excretion of CTL, another oxidative stress-related marker, is increased in patients with chronic renal failure (CRF). One hundred twenty-four non-dialyzed patients with chronic renal failure (serum Cr level, 1.3-10.0 mg/dL) were recruited from our hospitals. Urine and serum levels of CTL and MG were determined by high-performance liquid chromatography with the use of 9, 10- phenanthrenequinone as a fluorogenic reagent. The CTL/Cr and (CTL+MG)/Cr molar ratios in spot urine samples were also compared with those in 24-h urine samples. The urinary CTL/Cr and (CTL+MG)/Cr molar ratios increased with decreases in Cr clearance in patients with CRF. Correlations between serum and spot urine (CTL+MG)/Cr and between serum and spot urine CTL/Cr were quite similar to those in 24-h urine samples. CTL/Cr and (CTL+MG)/Cr molar ratios in both 24-h urine and spot urine samples appear to be useful indices of the severity of CRF.

Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Publishing Authors By Initials

K Ienaga,K Nakamura,T Fujisawa,Y Fukunaga,H Nihei,M Narita,Y Tomino,T Sanaka,K Aoyagi,K Nakano,H Koide,K Ienaga,K Nakamura,T Fujisawa,Y Fukunaga,H Nihei,M Narita,Y Tomino,T Sanaka,K Aoyagi,K Nakano,H Koide,

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Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Renal failure

VOLUME: 29

Page Numbers: 279-83

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ISSN: 0886-022X

DAY: 14

MONTH: 05

YEAR: 2007

Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure. Information

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LANGUAGE: eng

NlmUniqueID: 8701128

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Grant and Affiliation Information for Urinary excretion of creatol, an in vivo biomarker of hydroxyl radical, in patients with chronic renal failure.

AFFILIATION: Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co., Ltd, Hyogo, Japan.

Country: United States

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MEDLINETA: Ren Fail

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