Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women.

Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Research Abstract Details 

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Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Abstract Text:

Chisato Nagata,Tomoko Matsubara,Takeshi Hara,Hiroshi Fujita,Yasuko Nagao,Satoru Yamamoto,Chiken Shibuya,Yoshitomo Kashiki,Hiroyuki Shimizu,Chisato Nagata,Tomoko Matsubara,Takeshi Hara,Hiroshi Fujita,Yasuko Nagao,Satoru Yamamoto,Chiken Shibuya,Yoshitomo Kashiki,Hiroyuki Shimizu,

A protective role of melatonin in the etiology of breast cancer has been suggested. The down-regulation of estrogen secretion by melatonin is thought to be a main cause of the link between melatonin and breast cancer risk. The present cross-sectional study examined whether the urinary 6-sulfatoxymelatonin (aMT6-s) level is inversely associated with mammographic density, which is regarded as a marker of breast cancer risk. The study subjects were 289 Japanese women (175 premenopausal and 123 postmenopausal women) who were recruited from participants in a mammographic breast cancer screening. The size of the total breast area and that of the dense area were measured quantitatively using an automated mammographic mass detection method. The concentration of aMT6-s was measured using first-void morning urine. In premenopausal women, the urinary aMT6-s level was significantly positively associated with percent density after controlling for covariates (P for trend = 0.02). There was no significant association between urinary aMT6-s level and the percent density in postmenopausal women. We found no evidence that the melatonin level is inversely associated with mammographic density. (Cancer Epidemiol Biomarkers Prev 2007;16(11):2509-12).

Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Publishing Authors By Initials

C Nagata,T Matsubara,T Hara,H Fujita,Y Nagao,S Yamamoto,C Shibuya,Y Kashiki,H Shimizu,C Nagata,T Matsubara,T Hara,H Fujita,Y Nagao,S Yamamoto,C Shibuya,Y Kashiki,H Shimizu,

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Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer epidemiology, biomarkers & prevention : a p

VOLUME: 16

Page Numbers: 2509-12

Journal Abbreviation: Cancer Epidemiol. Biomarkers P

ISSN: 1055-9965

DAY: 16

MONTH: Nov

YEAR: 2007

Urinary 6-sulfatoxymelatonin and mammographic density in Japanese women. Information

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LANGUAGE: eng

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AFFILIATION: Department of Epidemiology and Preventive Medicine, Gifu University Graduate School of Medicine, 1-1 Yanagido, Gifu 501-1194, Japan. chisato@gifu-u.ac.jp.

Country: United States

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MEDLINETA: Cancer Epidemiol Biomarkers Pr

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