Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells.

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Abstract Text:

Zhongcai Ma,BongSook Jhun,Chad K Oh,Zhongcai Ma,BongSook Jhun,Chad K Oh,

Plasminogen activator inhibitor (PAI)-1 promotes development of asthma. PAI-1 mRNA and protein are markedly induced in activated mast cells (MCs), a major effector cell type in asthma. However, regulatory mechanisms of PAI-1 transcription in MCs are unknown. We present first evidence that PAI-1 is transcriptionally regulated in human MCs (hMCs). In addition to three enhancer regions, we demonstrated that the E-box at -566 bp to -561 bp is the negative regulatory element, and the specific and constitutive binding of the upstream stimulating factor-1 to this E-box is the key mechanism of the negative regulation of PAI-1 expression in hMCs.

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Publishing Authors By Initials

Z Ma,B Jhun,CK Oh,Z Ma,B Jhun,CK Oh,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: FEBS letters

VOLUME: 581

Page Numbers: 4485-90

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 27

MONTH: 08

YEAR: 2007

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 155157

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells.

AFFILIATION: University of California, Los Angeles, UCLA School of Medicine, Division of Allergy and Immunology, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, United States.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: FEBS Lett

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells Related Publications

• Aaptamines as sortase A inhibitors from the tropical sponge Aaptos aaptos.
• Activin receptor-like kinase 1 is essential for placental vascular development in mice.
• Alterations in intrinsic neuronal excitability during normal aging.
• Anxiolytic-like effects of obovatol isolated from Magnolia obovata: involvement of GABA/benzodiazepine receptors complex.
• Atrial fibrillation classification based on the spectrum pattern: is high frequency the target?
• Breast lesions with imaging-histologic discordance during US-guided 14G automated core biopsy: can the directional vacuum-assisted removal replace the surgical excision? Initial findings.
• Condom Carrying is Not Associated with Condom Use and Lower Prevalence of Sexually Transmitted Diseases Among Minority Adolescent Females.
• Current concepts of nociception: nociceptive molecular sensors in sensory neurons.
• Delayed-onset pineal abscess following transsphenoidal surgery for pituitary adenoma: a case report.
• Dominant role of the cbb3 oxidase in regulation of photosynthesis gene expression through the PrrBA system in Rhodobacter sphaeroides 2.4.1.
• EP practice in Korea.
• Effect of Leuconostoc spp. on the formation of Streptococcus mutans biofilm.
• Effective production of retinal from beta-carotene using recombinant mouse beta-carotene 15,15'-monooxygenase.
• Factors affecting the serum levels of adipokines in Korean male patients with nonalcoholic fatty liver disease.
• Hydroxy-alpha-sanshool activates TRPV1 and TRPA1 in sensory neurons.
• Inhibition of the pathogenicity of Magnaporthe grisea by bromophenols, isocitrate lyase inhibitors, from the red alga Odonthalia corymbifera.
• Insulin-like growth factor binding protein (IGFBP)-mediated hair cell survival on the mouse utricle exposed to neomycin: the roles of IGFBP-4 and IGFBP-5.
• Knockdown of Oct-4 or Sox-2 attenuates neurogenesis of mouse embryonic stem cells.
• Learning, aging and intrinsic neuronal plasticity.
• Prevalence of lower airway diseases in patients with chronic rhinosinusitis.
• Seroprevalence of Helicobacter pylori in South Korea.
• Tissue Doppler imaging a new prognosticator for cardiovascular diseases.
• Unruptured left main coronary artery aneurysm presented with acute cerebral infarction.
• Upstream stimulating factor-1 mediates the E-box-dependent transcriptional repression of the plasminogen activator inhibitor-1 gene in human mast cells.
• [Analysis of RN-BSN Students' Clinical Nursing Competency.]
• [Comparison of the metabolic syndrome risk factor prevalence forty and fifty something women]
• [Development of a mentoring program to improve exercise and dietary habits of adolescents.]
• [Factors Influencing Vitality among Nurses.]
• [Predictors of Participation in Support Groups among Women with Breast Cancer.]
• [Usefulness of DeltaMELD/month for prediction of the mortality in the first episode of variceal bleeding patients with liver cirrhosis: comparison with CTP, MELD score and DeltaCTP/month]