Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.

Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Research Abstract Details 

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Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Abstract Text:

Junki Inamura,Katsuya Ikuta,Junko Jimbo,Motohiro Shindo,Kazuya Sato,Yoshihiro Torimoto,Yutaka Kohgo,

Anemia of chronic disease (ACD) is commonly observed in chronic inflammation, although its pathogenesis is poorly understood. Hepcidin is thought to be a key regulator in iron metabolism and has been implicated in ACD. Although the induction of hepcidin by an inflammatory cytokine interleukin-6 (IL-6) seems to have been confirmed, it is still controversial whether interleukin-1beta (IL-1beta), also known as an inflammatory cytokine, regulates hepcidin expression. We demonstrated that hepcidin mRNA was upregulated by IL-1beta in human hepatoma-derived HuH-7 cells, particularly at low concentrations of IL-1beta, while high concentrations of IL-6 were needed for the upregulation of hepcidin mRNA. Therefore, IL-1beta might be more important for the upregulation of hepcidin in physiological conditions than IL-6. Although IL-1beta induces IL-6 production in hepatocytes, our data indicate that the effect of IL-1beta on hepcidin expression is independent from that of IL-6. In conclusion, IL-1beta might have an important role in ACD.

Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Publishing Authors By Initials

J Inamura,K Ikuta,J Jimbo,M Shindo,K Sato,Y Torimoto,Y Kohgo,

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Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Hepatology research : the official journal of the

VOLUME: 33

Page Numbers: 198-205

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ISSN: 1386-6346

DAY: 29

MONTH: 09

YEAR: 2005

Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines. Information

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LANGUAGE: eng

NlmUniqueID: 9711801

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Grant and Affiliation Information for Upregulation of hepcidin by interleukin-1beta in human hepatoma cell lines.

AFFILIATION: Third Department of Internal Medicine, Asahikawa Medical College, 2-1-1-1 Midorigaoka-Higashi, Asahikawa, Hokkaido 078-8510, Japan.

Country: Netherlands

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MEDLINETA: Hepatol Res

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