Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects.

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Research Abstract Details 

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Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Abstract Text:

Acetaminophen (paracetamol) is one of the most commonly used over-the-counter medications. Taken in doses greater than 150 mg/kg/day (>10 g), it usually causes acute liver failure. The authors review mainly the management of acetaminophen toxicity in both users and nonusers of alcohol. Chronic alcoholics are a special subgroup, who risk serious toxicity when taking acetaminophen, even in therapeutic doses. The acetaminophen-alcohol interaction is complex, because acute and chronic ethanol have opposite effects. This review also considers physiological and clinical changes, as well as the diagnosis and treatment of acetaminophen poisoning.

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Publishing Authors By Initials

For similar digestive system: liver research abstracts see: digestive system: liver research

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Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical pharmacy and therapeutics

VOLUME: 25

Page Numbers: 325-32

Journal Abbreviation: J Clin Pharm Ther

ISSN: 0269-4727

DAY: 28

MONTH: Oct

YEAR: 2000

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Information

Number of References: 80

LANGUAGE: eng

NlmUniqueID: 8704308

Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Keywords Mesh Terms:

KEYWORDS: Liver

MESH TERMS: drug effects

Chemical & Substance for Abstract: Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects. Information

Substance Name: Acetaminophen

Registry Number: 103-90-2

Grant and Affiliation Information for Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects.

AFFILIATION: Institute of Community Medicine, University of Tsukuba, Tsukuba-shi, Ibaraki-ken 305-8575, Japan. einosuke@md.tsukuba.ac.jp

Country: ENGLAND

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MEDLINETA: J Clin Pharm Ther

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