Update on surgery for Parkinson's disease.

Update on surgery for Parkinson's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Update on surgery for Parkinson's disease. Abstract Text:

Jens Volkmann,Jens Volkmann,

PURPOSE OF REVIEW: The clinical effectiveness and limitations of subthalamic nucleus deep brain stimulation for Parkinson's disease are summarized and recent developments concerning alternative brain targets for deep brain stimulation or restorative surgical therapies are discussed. RECENT FINDINGS: In a controlled study subthalamic nucleus deep brain stimulation was superior to best medical management in improving quality of life of patients with advanced Parkinson's disease. The benefits of the procedure on levodopa-sensitive motor symptoms are sustained for up to 5 years, but it does not halt disease progression. Cognitive decline and worsening of axial motor symptoms may limit the overall benefit. Age at the time of surgery is an important factor for long-term stability and safety. Psychosocial aspects of Parkinson's disease can profoundly impact on the ability of a patient to reintegrate after surgery and have to be considered in patient selection. Stimulation of the pedunculopontine nucleus may have an additive effect on postural and gait symptoms, which do not respond to levodopa or subthalamic nucleus deep brain stimulation. SUMMARY: Deep brain stimulation is emerging from an empirical to an evidence based therapy. The safety and efficacy of the procedure may legitimize surgery at a younger age before social maladjustment prevents reintegration of the patient into a normal life.

Update on surgery for Parkinson's disease. Publishing Authors By Initials

J Volkmann,J Volkmann,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Update on surgery for Parkinson's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Current opinion in neurology

VOLUME: 20

Page Numbers: 465-9

Journal Abbreviation: Curr. Opin. Neurol.

ISSN: 1350-7540

DAY: 10

MONTH: Aug

YEAR: 2007

Update on surgery for Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9319162

Update on surgery for Parkinson's disease. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Update on surgery for Parkinson's disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Update on surgery for Parkinson's disease.

AFFILIATION: Department of Neurology, Christian-Albrechts-University, Kiel, Germany. j.volkmann@neurologie.uni-kiel.de

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Curr Opin Neurol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Update on surgery for Parkinson's disease Related Publications

• Acrosomal damage and progressive motility of stallion semen forzen by two methods in 0.5-milliliter straws.
• Analysis of system structure-function relationships.
• Arabinogalactan-protein epitope Gal4 is differentially regulated and localized in cell lines of hybrid fir (Abies alba x Abies cephalonica) with different embryogenic and regeneration potential.
• Calreticulin mRNA and protein are localized to protein bodies in storage maize callus cells.
• Deep brain stimulation in Parkinson's disease following fetal nigral transplantation.
• Density-based score for selecting near-native atomic models of unknown structures.
• Ear protector valve. No. 2,458,884.
• Efficient automatic noise reduction of electron tomographic reconstructions based on iterative median filtering.
• Pallidal deep brain stimulation improves quality of life in segmental and generalized dystonia: Results from a prospective, randomized sham-controlled trial.
• Prevalence of micro-emboli in symptomatic high grade carotid artery disease: a transcranial Doppler study.
• Subthalamic nucleus stimulation modulates audiospinal reactions in Parkinson disease.
• Update on surgery for Parkinson's disease.
• [Dupuytren's contracture in all 4 extremities, induratio penis plastica, periarthritis humeroscapularis, keloids and pads on the finger knuckles.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Not Available.]
• [Pulmonary tuberculosis and surgery for abdominal affections, particularly for stomach tumors.]