Update on cyclooxygenase-2 inhibitors.

Update on cyclooxygenase-2 inhibitors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Update on cyclooxygenase-2 inhibitors. Abstract Text:

Raymond C Harris,Matthew D Breyer,

Nonsteroidal anti-inflammatory drugs represent the most commonly used medications for the treatment of pain and inflammation, but numerous well-described side effects can limit their use. Cyclooxygenase-2 (COX-2) inhibitors were initially touted as a therapeutic strategy to avoid not only the gastrointestinal but also the renal and cardiovascular side effects of nonspecific nonsteroidal anti-inflammatory drugs. However, in the kidney, COX-2 is constitutively expressed and is highly regulated in response to alterations in intravascular volume. COX-2 metabolites have been implicated in mediation of renin release, regulation of sodium excretion, and maintenance of renal blood flow. This review summarizes the current state of knowledge about both renal and cardiovascular side effects that are attributed to COX-2 selective inhibitors.

Update on cyclooxygenase-2 inhibitors. Publishing Authors By Initials

RC Harris,MD Breyer,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: water-electrolyte balance research

PUBMED ID PMID:

MEDLINE DATE:

Update on cyclooxygenase-2 inhibitors. Journal Published:

PUBLICATION TYPE: Review

Journal: Clinical journal of the American Society of Nephro

VOLUME: 1

Page Numbers: 236-45

Journal Abbreviation:

ISSN: 1555-905X

DAY: 1

MONTH: 02

YEAR: 2006

Update on cyclooxygenase-2 inhibitors. Information

Number of References: 150

LANGUAGE: eng

NlmUniqueID: 101271570

Update on cyclooxygenase-2 inhibitors. Keywords Mesh Terms:

KEYWORDS: Water-Electrolyte Balance

MESH TERMS: drug effects

Chemical & Substance for Abstract: Update on cyclooxygenase-2 inhibitors. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Update on cyclooxygenase-2 inhibitors.

AFFILIATION: Division of Nephrology, S3322 MCN, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. ray.harris@vanderbilt.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK62794

ACRONYM: DK

MEDLINETA: Clin J Am Soc Nephrol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Update on cyclooxygenase-2 inhibitors Related Publications

• A sensitized screen of N-ethyl-N-nitrosourea-mutagenized mice identifies dominant mutants predisposed to diabetic nephropathy.
• Apoptosis of the thick ascending limb results in acute kidney injury.
• Axial heterogeneity of vasopressin-receptor subtypes along the human and mouse collecting duct.
• Development and psychometric evaluation of the gambling treatment outcome monitoring system (GAMTOMS).
• Effect of selective cyclooxygenase-2 (COX-2) inhibitor treatment on glucose-stimulated insulin secretion in C57BL/6 mice.
• Glycogen synthase kinase 3 inhibition improves insulin-stimulated glucose metabolism but not hypertension in high-fat-fed C57BL/6J mice.
• PANCREATITIS-ITS TREATMENT, AS RELATED TO GALL-BLADDER INFECTION: REPORT OF CASES.
• Randomized clinical trial comparing sodium picosulfate with mannitol on the preparation FOR colonoscopy in hospitalized patients.
• SURGICAL TREATMENT OF CHRONIC PEPTIC ULCER.
• Single amino Acid substitution in aquaporin 11 causes renal failure.
• Stacking the deck for drug discovery in diabetic nephropathy: in search of an animal model.
• Thrombosis and Embolism: Preoperative and Postoperative Care in Their Prevention.
• Update on cyclooxygenase-2 inhibitors.
• [Anomalies of the uterus and pregnancy.]
• [Not Available.]
• [Physical therapy treatment of distal radius fractures]