Update on clindamycin in the management of bacterial, fungal and protozoal infections.

Update on clindamycin in the management of bacterial, fungal and protozoal infections. Research Abstract Details 

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Update on clindamycin in the management of bacterial, fungal and protozoal infections. Abstract Text:

David Guay,David Guay,

Lincomycin and clindamycin are the only members of the relatively small lincosamide antimicrobial class marketed for use in humans. This paper only reviews data regarding clindamycin, with an emphasis on data published over the last decade. Clindamycin exhibits a broad spectrum of antimicrobial activity, including Gram-positive aerobes/anaerobes, Gram-negative anaerobes and select protozoa (Toxoplasma gondii, Plasmodium falciparum, Babesia spp.) and fungi (Pneumocystis jiroveci). It still enjoys use in the therapy and prophylaxis of a large number of bacterial, protozoal and fungal infections, despite > 40 years of clinical use. However, the spectre of resistance by an increasing number of microorganisms is beginning to cast a shadow over the future use of this valuable agent. With the emergence and spread of infections due to community-acquired methicillin-resistant Staphylococci (for which clindamycin is a first-line agent), it is hoped that the issues of resistance can be mitigated and the use of clindamycin extended for at least the foreseeable future.

Update on clindamycin in the management of bacterial, fungal and protozoal infections. Publishing Authors By Initials

D Guay,D Guay,

For similar parasitic diseases: protozoan infections research abstracts see: parasitic diseases: protozoan infections research

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Update on clindamycin in the management of bacterial, fungal and protozoal infections. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert opinion on pharmacotherapy

VOLUME: 8

Page Numbers: 2401-44

Journal Abbreviation:

ISSN: 1744-7666

DAY: 29

MONTH: Oct

YEAR: 2007

Update on clindamycin in the management of bacterial, fungal and protozoal infections. Information

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LANGUAGE: eng

NlmUniqueID: 100897346

Update on clindamycin in the management of bacterial, fungal and protozoal infections. Keywords Mesh Terms:

KEYWORDS: Protozoan Infections

MESH TERMS: microbiology

Chemical & Substance for Abstract: Update on clindamycin in the management of bacterial, fungal and protozoal infections. Information

Substance Name: Clindamycin

Registry Number: 18323-44-9

Grant and Affiliation Information for Update on clindamycin in the management of bacterial, fungal and protozoal infections.

AFFILIATION: University of Minnesota, College of Pharmacy, Weaver-Densford Hall 7-148, 308 Harvard Street SE, Minneapolis, MN 55455, USA. guayx001@umn.edu

Country: England

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MEDLINETA: Expert Opin Pharmacother

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