Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta.

Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Research Abstract Details 

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Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Abstract Text:

Anne T French,Pamela A Knight,W David Smith,Jeremy K Brown,Nicola M Craig,Judith A Pate,Hugh R P Miller,Alan D Pemberton,Anne T French,Pamela A Knight,W David Smith,Jeremy K Brown,Nicola M Craig,Judith A Pate,Hugh R P Miller,Alan D Pemberton,

A novel intelectin molecule designated sheep intelectin 2 (sITLN2) was detected in sheep abomasal mucosa. The full sequence shared 76-83% homology with other mammalian intelectins. Intelectins are mucus-associated proteins that have been shown to be up-regulated in gastrointestinal nematode infections in rodents and in human asthma. Expression of sheep abomasal ITLN2 mRNA was significantly up-regulated on day 10 post-challenge of worm-free sheep with Teladorsagia circumcincta and at day 2 in previously infected, immune sheep. Increased expression of ITLN protein following challenge was confirmed by Western blot and was immunolocalised to the mucous neck cells of the abomasal mucosa. Infection with T. circumcincta was also associated with increased levels of abomasal transcripts encoding sheep mast cell protease-1, ovine galectin-14 and IL4, which collectively suggested a Th2 type response. Intelectin may play an important role in the mucosal response to gastrointestinal nematode infections in ruminants.

Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Publishing Authors By Initials

AT French,PA Knight,WD Smith,JK Brown,NM Craig,JA Pate,HR Miller,AD Pemberton,AT French,PA Knight,WD Smith,JK Brown,NM Craig,JA Pate,HR Miller,AD Pemberton,

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Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal for parasitology

VOLUME: 38

Page Numbers: 467-75

Journal Abbreviation: Int. J. Parasitol.

ISSN: 0020-7519

DAY: 1

MONTH: 10

YEAR: 2007

Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Up-regulation of intelectin in sheep after infection with Teladorsagia circumcincta.

AFFILIATION: Division of Veterinary Clinical Sciences, University of Edinburgh, Easter Bush Veterinary Centre, Roslin, Midlothian EH25 9RG, UK.

Country: England

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MEDLINETA: Int J Parasitol

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