Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Abstract Text:

Adam L Kruger,Stephen J Peterson,Michal L Schwartzman,Heidi Fusco,John A McClung,Melvin Weiss,Sylvia Shenouda,Alvin I Goodman,Michael S Goligorsky,Attallah Kappas,Nader G Abraham,

Heme oxygenase (HO) plays a critical role in the regulation of cellular oxidative stress. The effects of the reactive oxygen species scavenger ebselen and the HO inducers cobalt protoporphyrin and stannous chloride (SnCl(2)) on HO protein levels and activity, indices of oxidative stress, and the progression of diabetes were examined in the Zucker rat model of type 2 diabetes. The onset of diabetes coincided with an increase in HO-1 protein levels and a paradoxical decrease in HO activity, which was restored by administration of ebselen. Up-regulation of HO-1 expressed in the early development of diabetes produced a decrease in oxidative/nitrosative stress as manifested by decreased levels of 3-nitrotyrosine, superoxide, and cellular heme content. This was accompanied by a decrease in endothelial cell sloughing and reduced blood pressure. Increased HO activity was also associated with a significant increase in the antiapoptotic signaling molecules Bcl-xl and phosphorylation of p38-mitogen-activated protein kinase but no significant increases in Bcl-2 or BAD proteins. In conclusion, 3-nitrotyrosine, cellular heme, and superoxide, promoters of vascular damage, are reduced by HO-1 induction, thereby preserving vascular integrity and protecting cardiac function involving an increase in antiapoptotic proteins.

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Publishing Authors By Initials

AL Kruger,SJ Peterson,ML Schwartzman,H Fusco,JA McClung,M Weiss,S Shenouda,AI Goodman,MS Goligorsky,A Kappas,NG Abraham,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: mitogen-activated protein kinases: p38 mitogen-activated protein kinases research

PUBMED ID PMID:

MEDLINE DATE:

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of pharmacology and experimental thera

VOLUME: 319

Page Numbers: 1144-52

Journal Abbreviation: J. Pharmacol. Exp. Ther.

ISSN: 0022-3565

DAY: 7

MONTH: 09

YEAR: 2006

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 376362

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Keywords Mesh Terms:

KEYWORDS: p38 Mitogen-Activated Protein Kinases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects. Information

Substance Name: p38 Mitogen-Activated Protein Kinases

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.

AFFILIATION: Division of Cardiology, Department of Medicine, New York Medical College, Valhalla, New York 10595, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL55601

ACRONYM: HL

MEDLINETA: J Pharmacol Exp Ther

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects Related Publications

• 11,12-epoxyeicosatrienoic acid stimulates heme-oxygenase-1 in endothelial cells.
• A male patient with right-sided thoracic kidney, diabetes mellitus, hearing loss and renal dysfunction.
• A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells.
• A survey in India of doctors' knowledge, attitudes and practice regarding telemedicine and e-health.
• Association of carnitine deficiency in Indian continuous ambulatory peritoneal dialysis patients with anemia, erythropoietin use, residual renal function, and diabetes mellitus.
• Cleavage of the C-terminal serine of human alphaA-crystallin produces alphaA1-172 with increased chaperone activity and oligomeric size.
• Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells.
• Effect of oxidation of alphaA- and alphaB-crystallins on their structure, oligomerization and chaperone function.
• Genetic suppression of HO-1 exacerbates renal damage: reversed by an increase in the antiapoptotic signaling pathway.
• HMGB1 and LPS induce distinct patterns of gene expression and activation in neutrophils from patients with sepsis-induced acute lung injury.
• Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis.
• Hard metal lung disease: still hard to understand.
• Heme oxygenase-1 inhibition of Nox oxidase activation is a microvascular endothelial antioxidant effect of NO.
• Identification of a series of tetrahydroisoquinoline derivatives as potential therapeutic agents for breast cancer.
• Impact of silencing HO-2 on EC-SOD and the mitochondrial signaling pathway.
• Impaired CD8 T cell memory and CD4 T cell primary responses in IL-7R alpha mutant mice.
• Induction of heme oxygenase-1 in renovascular hypertension is associated with inhibition of apoptosis.
• Interdiction of the diabetic state in NOD mice by sustained induction of heme oxygenase: possible role of carbon monoxide and bilirubin.
• Involvement of the urokinase kringle domain in lipopolysaccharide-induced acute lung injury.
• Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats.
• Modulation of selenite cataract by the flavonoid fraction of Emilia sonchifolia in experimental animal models.
• Protection against selenite cataract in rat lens by drevogenin D, a triterpenoid aglycone from Dregea volubilis.
• Role of arginine-163 and the 163REEK166 motif in the oligomerization of truncated alphaA-crystallins.
• Systemic sclerosis: a prototypic multisystem fibrotic disorder.
• The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.
• Toll-like receptor 4 (TLR4) is required for protective immunity to larval Strongyloides stercoralis in mice.
• Up-regulation of heme oxygenase provides vascular protection in an animal model of diabetes through its antioxidant and antiapoptotic effects.
• Utility of tissue Doppler and strain echocardiography in arrhythmogenic right ventricular dysplasia/cardiomyopathy.
• Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity.
• Vascular abnormalities in primary amyloidosis.