Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats.

Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats. Research Abstract Details 

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Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats. Abstract Text:

Yuji Nakai,Hiroko Hashida,Koji Kadota,Michiko Minami,Kentaro Shimizu,Ichiro Matsumoto,Hisanori Kato,Keiko Abe,Yuji Nakai,Hiroko Hashida,Koji Kadota,Michiko Minami,Kentaro Shimizu,Ichiro Matsumoto,Hisanori Kato,Keiko Abe,Yuji Nakai,Hiroko Hashida,Koji Kadota,Michiko Minami,Kentaro Shimizu,Ichiro Matsumoto,Hisanori Kato,Keiko Abe,

The functional balance between brown adipose tissue (BAT) and white adipose tissue (WAT) is important for metabolic homeostasis. We compared the effects of fasting on the gene expression profiles in BAT, WAT and liver by using a DNA microarray analysis. Tissues were obtained from rats that had been fed or fasted for 24 h. Taking the false discovery rate into account, we extracted the top 1,000 genes that had been differentially expressed between the fed and fasted rats. In all three tissues, a Gene Ontology analysis revealed that the lipid and protein biosynthesis-related genes had been markedly down-regulated. The whole-body fuel shift from glucose to triacylglycerol and the induction of autophagy were also observed. There was marked up-regulation of genes in the 'protein ubiquitination' category particularly in BAT of the fasted rats, suggesting that the ubiquitin-proteasome system was involved in saving energy as an adaptation to food shortage.

Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats. Publishing Authors By Initials

Y Nakai,H Hashida,K Kadota,M Minami,K Shimizu,I Matsumoto,H Kato,K Abe,Y Nakai,H Hashida,K Kadota,M Minami,K Shimizu,I Matsumoto,H Kato,K Abe,Y Nakai,H Hashida,K Kadota,M Minami,K Shimizu,I Matsumoto,H Kato,K Abe,

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Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 72

Page Numbers: 139-48

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 1347-6947

DAY: 7

MONTH: 01

YEAR: 2008

Up-regulation of genes related to the ubiquitin-proteasome system in the brown adipose tissue of 24-h-fasted rats. Information

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LANGUAGE: eng

NlmUniqueID: 9205717

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AFFILIATION: Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. yunakai@iu.a.u-tokyo.ac.jp

Country: Japan

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MEDLINETA: Biosci Biotechnol Biochem

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