Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia.

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Abstract Text:

John E Wagner,Mary Eapen,Margaret L MacMillan,Richard E Harris,Ricardo Pasquini,Farid Boulad,Mei-Jie Zhang,Arleen D Auerbach,

Bone marrow transplantation (BMT) is the only known cure for the hematologic manifestations of Fanconi anemia (FA). Potential benefits of unrelated donor BMT for FA, however, have been severely limited by graft rejection and treatment-related mortality with resultant poor survival. Therefore, we evaluated the impact of potential prognostic factors on hematopoietic recovery, graft-versus-host disease (GVHD), and mortality in 98 recipients of unrelated donor BMT who received transplants between 1990 and 2003. Probabilities of neutrophil (89% vs 69%; P = .02) and platelet (74% vs 23%; P < .001) recovery were higher after fludarabine-containing regimens than nonfludarabine-containing regimens. Risks of acute GVHD (relative risk [RR], 4.29; P < .001) were higher with non-T-cell-depleted grafts. The day-100 mortality rate was significantly higher after nonfludarabine-containing regimens than fludarabine-containing regimens (65% vs 24%, respectively; P < .001). Corresponding 3-year adjusted overall survival rates were 13% versus 52% (P < .001). In addition, mortality was higher in recipients who were older (> 10 years), who were cytomegalovirus (CMV) seropositive, and who received more than 20 blood product transfusions before BMT. Based on these results, significant practice changes are suggested: use of a fludarabine-containing conditioning regimen in the context of T-cell-depleted marrow allografts, and earlier referral for transplantation prior to excessive transfusions in patients with marrow failure.

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Publishing Authors By Initials

JE Wagner,M Eapen,ML MacMillan,RE Harris,R Pasquini,F Boulad,MJ Zhang,AD Auerbach,

For similar persons: tissue donors research abstracts see: persons: tissue donors research

PUBMED ID PMID:

MEDLINE DATE:

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Blood

VOLUME: 109

Page Numbers: 2256-62

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 12

MONTH: 10

YEAR: 2006

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7603509

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Keywords Mesh Terms:

KEYWORDS: Tissue Donors

MESH TERMS: cytology

Chemical & Substance for Abstract: Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia.

AFFILIATION: Division of Pediatric Hematology, Oncology, and Blood and Marrow Transplantation, University of Minnesota Blood and Marrow Transplant Program, Minneapolis, MN 55455, USA. wagne002@umn.edu

Country: United States

AGENCY: United States NCI

GRANT: U24-CA76518-08

ACRONYM: CA

MEDLINETA: Blood

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia Related Publications

• A molecular scheme for improved characterization of human embryonic stem cell lines.
• Acetylcholine Receptor Gating: Movement in the {alpha}-Subunit Extracellular Domain.
• Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-m1" linker.
• Acetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and m2 m3 linker.
• An advanced molecule-surface scattering instrument for study of vibrational energy transfer in gas-solid collisions.
• Anesthesia in endodontia.
• Chemical mutagenesis.
• Determination of homosulfanilamide hydrochloride, with observations on its absorption in dogs and man.
• Directory of organizations in America, of and for the deaf.
• Emphysema: smoking's irreversible legacy.
• Empyema as a complication of chronic pulmonary tuberculosis.
• Genetic heterogeneity among Fanconi anemia heterozygotes and risk of cancer.
• How to turn the reaction coordinate into time.
• Impact of reliance on CT pulmonary angiography on diagnosis of pulmonary embolism: a Bayesian analysis.
• Microwave-driven zeolite-guest systems show athermal effects from nonequilibrium molecular dynamics.
• Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux.
• Operationalizing the "vulnerability" and "stress" components of the hopelessness theory of depression: a multi-wave longitudinal study.
• Outcomes of care by hospitalists, general internists, and family physicians.
• Physiology of the pulpless tooth; is the pulpless tooth a dead tooth?
• Primary motor area activation during precision-demanding versus simple finger movement.
• Production of functional transgenic mice by DNA pronuclear microinjection.
• Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.
• Qualification of embryonal carcinoma 2102Ep as a reference for human embryonic stem cell research.
• Responses to depression in children: reconceptualizing the relation among response styles.
• THE METABOLISM OF HISTIDINE. VI. HISTIDINEMIA AND IMIDAZOLEPYRUVIC ACIDURIA.
• The action of cationic detergents on bacteria and bacterial enzymes.
• The pathology of carcinoma of the bronchus.
• The relevance and future of wilderness medicine.
• Tuberculosis in children.
• Unrelated donor bone marrow transplantation for the treatment of Fanconi anemia.