Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly.

Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Research Abstract Details 

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Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Abstract Text:

Samantha A Roberts,Gordon G Churchward,June R Scott,

The response regulator CovR acts as a master regulator of virulence in Streptococcus pyogenes by repressing transcription of approximately 15% of the group A streptococcus genome directly or indirectly. We demonstrate that phosphorylated CovR represses transcription of rivR directly by binding to conserved sequences located downstream from the promoter to block procession of RNA polymerase. This establishes the first link in a regulatory network where CovR interacts directly with other proteins that modulate gene expression.

Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Publishing Authors By Initials

SA Roberts,GG Churchward,JR Scott,

For similar biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: virulence research abstracts see: biological phenomena, cell phenomena, and immunity: biological phenomena: microbiologic phenomena: virulence research

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Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of bacteriology

VOLUME: 189

Page Numbers: 1459-63

Journal Abbreviation: J. Bacteriol.

ISSN: 0021-9193

DAY: 8

MONTH: 09

YEAR: 2006

Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985120

Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Keywords Mesh Terms:

KEYWORDS: Virulence

MESH TERMS: pathogenicity

Chemical & Substance for Abstract: Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly. Information

Substance Name: Repressor Proteins

Registry Number: 0

Grant and Affiliation Information for Unraveling the regulatory network in Streptococcus pyogenes: the global response regulator CovR represses rivR directly.

AFFILIATION: Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NIAID

GRANT: T32-AI07470

ACRONYM: AI

MEDLINETA: J Bacteriol

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