Unraveling the mysteries of IGF-1 signaling in melanoma.

Unraveling the mysteries of IGF-1 signaling in melanoma. Research Abstract Details 

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Unraveling the mysteries of IGF-1 signaling in melanoma. Abstract Text:

The inherent ability of a cell to undergo apoptosis governs a number of developmental processes essential to proper mammalian development. Into adulthood, the pathways that potentiate the apoptotic response are extremely diverse and finely regulated to prevent potential diseases. Of these, cancer is often associated with loss of an apoptotic response. Hanahan and Weinberg (2000) list evasion of apoptosis as a hallmark feature acquired during neoplastic transformation. The impact of this event is dramatic on several levels; avoidance of apoptosis not only prevents programmed cell death in an array of cell types but also promotes chemotherapeutic resistance during anticancer regimens.

Unraveling the mysteries of IGF-1 signaling in melanoma. Publishing Authors By Initials

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Unraveling the mysteries of IGF-1 signaling in melanoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of investigative dermatology

VOLUME: 128

Page Numbers: 1358-60

Journal Abbreviation: J. Invest. Dermatol.

ISSN: 1523-1747

DAY: 14

MONTH: Jun

YEAR: 2008

Unraveling the mysteries of IGF-1 signaling in melanoma. Information

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LANGUAGE: eng

NlmUniqueID: 426720

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Grant and Affiliation Information for Unraveling the mysteries of IGF-1 signaling in melanoma.

AFFILIATION: Department of Molecular & Cellular Oncogenesis, The Wistar Institute, Philadelphia, PA 19104, USA.

Country: United States

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MEDLINETA: J Invest Dermatol

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