Universal newborn screening and adverse medical outcomes: a historical note.

Universal newborn screening and adverse medical outcomes: a historical note. Research Abstract Details 

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Universal newborn screening and adverse medical outcomes: a historical note. Abstract Text:

Jeffrey P Brosco,Michael I Seider,Angela C Dunn,

Universal newborn screening programs for metabolic disorders are typically described as a triumph of medicine and public policy in the US over the last 50 years. Advances in science and technology, including the Human Genome Project, offer the opportunity to expand universal newborn screening programs to include many additional metabolic and genetic conditions. Although the benefits of such screening programs appear to outweigh their costs, some critics have claimed that historical examples of inadvertent harm ensuing from false-positive screening results and subsequent inappropriate medical treatment should make us wary of expanding universal newborn screening. In this essay, we report the results of a review of the published literature to assess whether the extension of screening from at risk populations to all newborns led to substantial morbidity and mortality from misguided medical treatment. We provide a historical overview of universal newborn screening programs in the United States, and then focus on six early NBS programs: congenital hypothyroidism, phenylketonuria, congenital adrenal hyperplasia, galactosemia, sickle cell disease, and maple syrup urine disease. Our comprehensive search of published sources did not reveal a widespread problem of harm ensuing from medical treatment of children with false positive screening test results.

Universal newborn screening and adverse medical outcomes: a historical note. Publishing Authors By Initials

JP Brosco,MI Seider,AC Dunn,

For similar geographic locations: americas: north america: united states research abstracts see: geographic locations: americas: north america: united states research

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Universal newborn screening and adverse medical outcomes: a historical note. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Mental retardation and developmental disabilities

VOLUME: 12

Page Numbers: 262-9

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ISSN: 1080-4013

DAY: 3

MONTH: 12

YEAR: 2006

Universal newborn screening and adverse medical outcomes: a historical note. Information

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LANGUAGE: eng

NlmUniqueID: 9517974

Universal newborn screening and adverse medical outcomes: a historical note. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: history

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Grant and Affiliation Information for Universal newborn screening and adverse medical outcomes: a historical note.

AFFILIATION: Department of Pediatrics, University of Miami, Miller School of Medicine, Miami, Florida 33101, USA. jbrosco@miami.edu

Country: United States

AGENCY: United States PHS

GRANT: 06-C210-01

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MEDLINETA: Ment Retard Dev Disabil Res Re

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