Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism.

Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Research Abstract Details 

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Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Abstract Text:

A Ganguly,M N Yum,J H Pratt,M H Weinberger,C E Grim,H Y Yune,J P Donohue,

In 3 patients with longstanding hypertension and spontaneous or diuretic-induced hypokalemia, the diagnosis of primary aldosteronism was established by the dual criteria of non-suppressible plasma aldosterone level and suppressed plasma renin activity. Preoperative studies of the etiology for the hyperaldosteronism using the postural plasma aldosterone test and adrenal venous steroid measurements gave conflicting results. On the basis of the differential adrenal venous steroid content, which suggested an unilateral adrenal source for the aldosterone hypersecretion, presumed to be adrenal adenoma, each patient was operated upon. In each case the excised adrenal revealed adenomatous or macronodular hyperplasia. Reinvestigation of the patients 3 to 12 months after the adrenalectomy showed that the dynamics of the renin-aldosterone axis was now restored to the normal state even though the patients remained hypertensive. These findings indicate that unilateral hypersecretion of aldosterone associated with adrenal hyperplasia can occur in some patients with primary aldosteronism simulating that due to an aldosteronoma. Such observations also raise questions about the pathogenesis of the adrenal hyperplasia and seem to add further complexity to the evaluation of patients with hyperaldosteronism.

Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Publishing Authors By Initials

A Ganguly,MN Yum,JH Pratt,MH Weinberger,CE Grim,HY Yune,JP Donohue,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: aspartic endopeptidases: renin research

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Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 5

Page Numbers: 1635-58

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1983

Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Keywords Mesh Terms:

KEYWORDS: Renin

MESH TERMS: blood

Chemical & Substance for Abstract: Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Unilateral hypersecretion of aldosterone associated with adrenal hyperplasia as a cause of primary aldosteronism.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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