Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome.

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Abstract Text:

Ramesh Ganapathy,Ronald F Lamont,Paul Bassett,Ramesh Ganapathy,Ronald F Lamont,Paul Bassett,

OBJECTIVE: To investigate the association between unexplained elevated maternal serum beta-Human chorionic gonadotrophin (HCG) in the second trimester of pregnancy and adverse pregnancy outcome. METHODS: In a case-controlled study of 3463 women who opted for second-trimester serum screening for Down syndrome, 142 were found to have a serum beta-HCG of > or =3.5 multiples of the median (MoM), 56 of whom had a serum beta-HCG of > or =5.0 MoM. These women were compared with a control group of women with serum beta-HCG within the 95% confidence interval around the median. RESULTS: In the elevated beta-HCG group (> or =5 MoM) significantly more babies required admission to the special care baby unit (p = 0.02) and were small for gestational age (SGA) (p = 0.03). The mean birth weight was also significantly lower in the group with elevated beta-HCG. Women with a serum beta-HCG of > or =5, > or =6, > or =7 or > or =8 MoM were associated with SGA babies in 40, 44, 64 and 86% respectively. All babies born to the six women with beta-HCG of 8.75-24.1 MoM were SGA. CONCLUSION: Increased surveillance is necessary in pregnancies where the maternal serum beta-HCG in the second trimester is inexplicably elevated to > or =5 MoM.

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Publishing Authors By Initials

R Ganapathy,RF Lamont,P Bassett,R Ganapathy,RF Lamont,P Bassett,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Prenatal diagnosis

VOLUME: 27

Page Numbers: 995-9

Journal Abbreviation: Prenat. Diagn.

ISSN: 0197-3851

DAY: 29

MONTH: Nov

YEAR: 2007

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8106540

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome.

AFFILIATION: Department of Obstetrics and Gynaecology, Northwick Park Hospital, North-West London, NHS Trust, London, UK.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Prenat Diagn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome Related Publications

• A cognitive systematic approach to analyzing preparation design for a difficult space management case.
• A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer's disease.
• Action of soda lime on chloroform.
• Comparison of Accelerometer Counts Between the ActiGraph and Actical During Structured Field Activities: 1304: Board #67 May 30 11:00 AM -12:30 PM.
• Complementary light and electron microscope investigations on the habit and structure of crystals with particular reference to long chain compounds.
• Diagnosis of Achilles tendon xanthoma in patients with heterozygous familial hypercholesterolemia: MR vs sonography.
• Diagnostic oncology case study: lytic spine lesion and cold bone scan.
• Gender and blindness: eye disease and the use of eye care services.
• Intracranial aneurysms; some clinical observations concerning their development.
• Intravenous angiotensin and salt appetite in rats.
• Iron and hepatitis C: beginning to make sense.
• MR imaging of the breast in patients with silicone-gel implants: spectrum of findings.
• Mammographic findings after the removal of breast implants.
• Mammographic findings of diffuse amyloidosis and carcinoma of the breast.
• Metabolic studies on protein-depleted patients receiving a large part of their nitrogen intake from human serum albumin administered intravenously.
• Muscle injury potentials: a source of voltage in the undeformed rabbit tibia.
• Ovarian mass, bone metastases, and a breast lesion.
• Psychosomatic theory applies to sex above all else.
• Randomized open-label trial of two simplified, class-sparing regimens following a first suppressive three or four-drug regimen.
• Recognizing a common genetic syndrome: 22q11.2 deletion syndrome.
• Relationships between clinical signs, pathological changes and tissue distribution of Mycobacterium avium subspecies paratuberculosis in 21 cows from herds affected by Johne's disease.
• Silicone breast implant rupture: comparison between three-point Dixon and fast spin-echo MR imaging.
• Surgical treatment of hypertension; present concepts.
• Symptomatic bursa formation with osteochondromas.
• The effect of leucotomy on creative ability.
• The histone variant CENP-A and centromere specification.
• The lutein cell population and mitotic activity in the corpus luteum of pregnancy in the albino rat.
• The problem of electroencephalographic contribution to the differential diagnosis of localized intracranial lesions.
• Unexplained elevated maternal serum beta-HCG concentration and adverse pregnancy outcome.
• [Epidemiology of AIDS and HIV infection in the Caribbean]