Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy.

Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Research Abstract Details 

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Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Abstract Text:

H Tsukamoto,T Ishikawa,Y Fujii,M Fukumizu,K Sugai,T Kanbayashi,H Tsukamoto,T Ishikawa,Y Fujii,M Fukumizu,K Sugai,T Kanbayashi,

We report on two prepubertal narcoleptic boys with undetectable levels of hypocretin-1 (orexin-A) in their cerebrospinal fluid (CSF). The disease onset times were 6 and 8 years, and CSF was collected 8 and 20 months after the onset, respectively. The initial symptoms were excessive daytime sleepiness, cataplexy and disrupted nocturnal sleep. Both subjects are DRB1*1501 and DQB1*0602 positive. The measurement of CSF hypocretin-1 is valuable for the decisive diagnosis of narcolepsy and for selecting the type of treatment in prepubertal children. Our results suggest that a significant degree of hypocretin deficiency is already present at the disease onset.

Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Publishing Authors By Initials

H Tsukamoto,T Ishikawa,Y Fujii,M Fukumizu,K Sugai,T Kanbayashi,H Tsukamoto,T Ishikawa,Y Fujii,M Fukumizu,K Sugai,T Kanbayashi,

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Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuropediatrics

VOLUME: 33

Page Numbers: 51-2

Journal Abbreviation: Neuropediatrics

ISSN: 0174-304X

DAY: 16

MONTH: Feb

YEAR: 2002

Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Information

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LANGUAGE: eng

NlmUniqueID: 8101187

Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Keywords Mesh Terms:

KEYWORDS: Neuropeptides

MESH TERMS: cerebrospinal fluid

Chemical & Substance for Abstract: Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy. Information

Substance Name: orexins

Registry Number: 0

Grant and Affiliation Information for Undetectable levels of CSF hypocretin-1 (orexin-A) in two prepubertal boys with narcolepsy.

AFFILIATION: Department of Pediatrics, Nagoya City University Medical School, Nagoya, Japan. Harukot@aol.com

Country: Germany

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MEDLINETA: Neuropediatrics

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