Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1).

Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Research Abstract Details 

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Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Abstract Text:

John H Laity,Glen K Andrews,

The regulation of divalent zinc has been observed in a wide range of organisms. Since this metal is an essential nutrient, but also toxic in excess, zinc homeostasis is crucial for normal cellular functioning. The metal-responsive-element-binding transcription factor-1 (MTF-1) is a key regulator of zinc in higher eukaryotes ranging from insects to mammals. MTF-1 controls the expression of metallothioneins (MTs) and a number of other genes directly involved in the intracellular sequestration and transport of zinc. Although the diverse functions of MTF-1 extend well beyond zinc homeostasis to include stress-responses to heavy metal toxicity, oxidative stress, and selected chemical agents, in this review we focus on the recent advances in understanding the mechanisms whereby MTF-1 regulates MT gene expression to protect the cell from fluctuations in environmental zinc. Particular emphasis is devoted to recent studies involving the Cys2His2 zinc finger DNA-binding domain of MTF-1, which is an important contributor to the zinc-sensing and metal-dependent transcriptional activation functions of this protein.

Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Publishing Authors By Initials

JH Laity,GK Andrews,

For similar zinc fingers research abstracts see: zinc fingers research

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Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Journal Published:

PUBLICATION TYPE: Review

Journal: Archives of biochemistry and biophysics

VOLUME: 463

Page Numbers: 201-10

Journal Abbreviation: Arch. Biochem. Biophys.

ISSN: 0003-9861

DAY: 4

MONTH: 04

YEAR: 2007

Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Information

Number of References: 138

LANGUAGE: eng

NlmUniqueID: 372430

Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Keywords Mesh Terms:

KEYWORDS: Zinc Fingers

MESH TERMS: metabolism

Chemical & Substance for Abstract: Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1). Information

Substance Name: Metallothionein

Registry Number: 9038-94-2

Grant and Affiliation Information for Understanding the mechanisms of zinc-sensing by metal-response element binding transcription factor-1 (MTF-1).

AFFILIATION: Division of Cell Biology and Biophysics, School of Biological Sciences, University of Missouri-Kansas City, Kansas City, MO 64110-2499, USA. laityj@umkc.edu

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES05704

ACRONYM: ES

MEDLINETA: Arch Biochem Biophys

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