Understanding systemic sclerosis through gene expression profiling.

Understanding systemic sclerosis through gene expression profiling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Understanding systemic sclerosis through gene expression profiling. Abstract Text:

Sarah A Pendergrass,Michael L Whitfield,Humphrey Gardner,Sarah A Pendergrass,Michael L Whitfield,Humphrey Gardner,

PURPOSE OF REVIEW: Genomic analysis has rapidly become commonplace in the study and treatment of complex disease. Several recent studies of gene expression profiling in systemic sclerosis have demonstrated its value in diagnosis and illustrate the potential for this technique in prognostication, as well as the elucidation of the underlying pathogenesis. RECENT FINDINGS: Skin biopsies from patients with systemic sclerosis show robust changes in gene profile that precede clinically detectable involvement. Current results suggest that clinically indistinguishable subgroups may be identified with different pathogenesis and outcome. Expression profiling studies of animal models of systemic sclerosis and explanted fibroblasts have helped to reveal the utility and deficiencies of these surrogates in the study of systemic sclerosis. SUMMARY: Gene profiling is likely to provide valuable prognostic information in systemic sclerosis patients. Recent advances in sample collection and standardization of analysis mean that longitudinal collection of samples for gene profiling, even in small numbers of patients from different clinical centers, will contribute enormously to our understanding of the disease.

Understanding systemic sclerosis through gene expression profiling. Publishing Authors By Initials

SA Pendergrass,ML Whitfield,H Gardner,SA Pendergrass,ML Whitfield,H Gardner,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Understanding systemic sclerosis through gene expression profiling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current opinion in rheumatology

VOLUME: 19

Page Numbers: 561-7

Journal Abbreviation:

ISSN: 1040-8711

DAY: 5

MONTH: Nov

YEAR: 2007

Understanding systemic sclerosis through gene expression profiling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9000851

Understanding systemic sclerosis through gene expression profiling. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Understanding systemic sclerosis through gene expression profiling. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Understanding systemic sclerosis through gene expression profiling.

AFFILIATION: Department of Genetics, Norris Cotton Cancer Center, Dartmouth Medical School, Hanover, New Hampshire, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: AR007576

ACRONYM: AR

MEDLINETA: Curr Opin Rheumatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Understanding systemic sclerosis through gene expression profiling Related Publications

• A witnessed short fall mimicking presumed shaken baby syndrome (inflicted childhood neurotrauma).
• CTnDOT integrase performs ordered homology-dependent and homology-independent strand exchanges.
• Cardiopulmonary resuscitation in pregnancy.
• Characterization of a conjugative transposon integrase, IntDOT.
• Comparison of morphological effects of PGE2 and TGFbeta on osteoclastogenesis induced by RANKL in mouse bone marrow cell cultures.
• Cooperation peaks at intermediate disturbance.
• Differences in vascular reactivity between men and women.
• Discrimination of prostate cancer cells by reflection mode FTIR photoacoustic spectroscopy.
• Dynamic programming algorithms for comparing multineuronal spike trains via cost-based metrics and alignments.
• Embryo culture medium: which is the best?
• Fatal pneumococcal meningitis: failure of acute care focus of medical practice.
• Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma.
• In vitro combination characterization of the new anticancer plant drug beta-elemene with taxanes against human lung carcinoma.
• Incurring greater health care costs: risk stratification of employees with bipolar disorder.
• IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT.
• Interaction of the Gifsy-1 Xis protein with the Gifsy-1 attP sequence.
• Large-scale mapping and validation of Escherichia coli transcriptional regulation from a compendium of expression profiles.
• Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats.
• Optical artefacts in transflection mode FTIR microspectroscopic images of single cells on a biological support: the effect of back-scattering into collection optics.
• Previous traumatic birth: an impetus for requested cesarean birth.
• Selective leukemic-cell killing by a novel functional class of thalidomide analogs.
• Surviving change: Can the ESRD provisions in the SCHIP create a level playing field?
• The bacteroides NBU1 integrase performs a homology-independent strand exchange to form a holliday junction intermediate.
• The core role of the nurse practitioner: practice, professionalism and clinical leadership.
• The effect of current cigarette smoking on calf muscle hemoglobin oxygen saturation in patients with intermittent claudication.
• The influence of obesity on arterial compliance in adult men and women.
• The relationship between arterial elasticity and metabolic syndrome features.
• Transcriptional repression by a conserved intronic sequence in the nicotinic receptor alpha3 subunit gene.
• Understanding systemic sclerosis through gene expression profiling.
• Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells.