Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research.

Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Research Abstract Details 

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Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Abstract Text:

Perng-Kuang Chang,Kenichiro Matsushima,Tadashi Takahashi,Jiujiang Yu,Keietsu Abe,Deepak Bhatnagar,Gwo-Fang Yuan,Yasuji Koyama,Thomas E Cleveland,

Aspergillus section Flavi includes aflatoxin-producing and nonproducing fungi. Aspergillus sojae is unable to produce aflatoxins and is generally recognized as safe for food fermentation. However, because of its taxonomical relatedness to aflatoxin-producing Aspergillus parasiticus and A. flavus, it is necessary to decipher the underlying mechanisms for its inability to produce aflatoxins. This review addresses the relationship between A. sojae and A. parasiticus and the advances that have been made in aflatoxin biosynthesis research, especially with regard to gene structure, genome organization, and gene regulation in A. parasiticus and A. flavus and how this has been used to assure the safety of A. sojae as an organism for food fermentation. The lack of aflatoxin-producing ability of A. sojae results primarily from an early termination point mutation in the pathway-specific aflR regulatory gene, which causes the truncation of the transcriptional activation domain of AflR and the abolishment of interaction between AflR and the AflJ co-activator. Both are required for gene expression. In addition, a defect in the polyketide synthase gene also contributes to its nonaflatoxigenicity.

Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Publishing Authors By Initials

PK Chang,K Matsushima,T Takahashi,J Yu,K Abe,D Bhatnagar,GF Yuan,Y Koyama,TE Cleveland,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Journal Published:

PUBLICATION TYPE: Review

Journal: Applied microbiology and biotechnology

VOLUME: 76

Page Numbers: 977-84

Journal Abbreviation: Appl. Microbiol. Biotechnol.

ISSN: 0175-7598

DAY: 31

MONTH: 07

YEAR: 2007

Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Information

Number of References: 80

LANGUAGE: eng

NlmUniqueID: 8406612

Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: metabolism

Chemical & Substance for Abstract: Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research. Information

Substance Name: Transcription Factors

Registry Number: 0

Grant and Affiliation Information for Understanding nonaflatoxigenicity of Aspergillus sojae: a windfall of aflatoxin biosynthesis research.

AFFILIATION: Food and Feed Safety Research Unit, Southern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 1100 Robert E. Lee Boulevard, New Orleans, LA 70124, USA. pkchang@srrc.ars.usda.gov

Country: Germany

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MEDLINETA: Appl Microbiol Biotechnol

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