Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease.

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Abstract Text:

Takahiko Nakagawa,

In many forms of experimental kidney diseases, renal VEGF is low, and administering VEGF can be shown to be protective. A paradox occurs in diabetes, in which renal VEGF levels are high and a deleterious effect of VEGF on kidney disease has been shown. We have hypothesized that endothelial dysfunction induced by hyperglycemia or other factors may underlie the pathogenic mechanisms of a high VEGF state. VEGF normally stimulates endothelial nitric oxide (NO) release and acts in concert with elevated NO levels as a trophic factor for vascular endothelium. The increased NO derived from the endothelial cell acts as an inhibitory factor that prevents excess endothelial cell proliferation, vascular smooth muscle cell proliferation, and macrophage infiltration. In the setting where NO bioavailability is reduced in diabetes, high levels of VEGF lead to excessive endothelial cell proliferation, stimulation of macrophage chemotaxis, and vascular smooth muscle cell activation. Consistent with this hypothesis is our recent observation that diabetes induced in endothelial NO-deficient mice results in clinical and histological features identical to human diabetic nephropathy. The discovery of the key role for impaired endothelial NO bioavailability in the stimulation of VEGF and VEGF-dependent disease may provide key insights into not only the pathogenesis of diabetic nephropathy but also the utility and hazard of administering VEGF as a treatment for kidney disease.

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Publishing Authors By Initials

T Nakagawa,

For similar peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research abstracts see: peptides: intercellular signaling peptides and proteins: angiogenic proteins: vascular endothelial growth factors: vascular endothelial growth factor a research

PUBMED ID PMID:

MEDLINE DATE:

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Journal Published:

PUBLICATION TYPE: Review

Journal: American journal of physiology. Renal physiology

VOLUME: 292

Page Numbers: F1665-72

Journal Abbreviation: Am. J. Physiol. Renal Physiol.

ISSN: 0363-6127

DAY: 3

MONTH: Jun

YEAR: 2007

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Information

Number of References: 78

LANGUAGE: eng

NlmUniqueID: 100901990

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Keywords Mesh Terms:

KEYWORDS: Vascular Endothelial Growth Factor A

MESH TERMS: toxicity

Chemical & Substance for Abstract: Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease. Information

Substance Name: Nitric Oxide Synthase Type III

Registry Number: EC 1.14.13.39

Grant and Affiliation Information for Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease.

AFFILIATION: Division of Nephrology, Hypertension, and Transplantation, University of Florida, PO Box 100224, Gainesville, FL 32610-0224, USA. nakagt@medicine.ufl.edu

Country: United States

AGENCY: United States NIDDK

GRANT: DK-52121

ACRONYM: DK

MEDLINETA: Am J Physiol Renal Physiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease Related Publications

• 11-Deoxyalisol C and Alisol D: New Protostane-Type Triterpenoids from Alisma plantago-aquatica.
• A case of angioedema associated with decreased C1 inhibitor activity.
• A neural network model of metaphor understanding with dynamic interaction based on a statistical language analysis: targeting a human-like model.
• An adult form of Alexander disease: a novel mutation in glial fibrillary acidic protein.
• Characterization of progenitor domains in the developing mouse thalamus.
• Delay of cataract development in the shumiya cataract rat by the administration of drinking water containing high concentration of magnesium ion.
• Effects of frequency characteristics of reverberation time on listener envelopment.
• Efficacy of living donor liver transplantation for patients with methylmalonic acidemia.
• Efficient generation of antigen-specific cellular immunity by vaccination with poly(gamma-glutamic acid) nanoparticles entrapping endoplasmic reticulum-targeted peptides.
• Fractal-based EEG data analysis of body parts movement imagery tasks.
• Fructose, but not dextrose, accelerates the progression of chronic kidney disease.
• Gamma-aminobutyric acid (GABA) stimulates pancreatic cancer growth through overexpressing GABAA receptor pi subunit.
• Glutathione S-transferase M1 null genotype as a risk factor for carbamazepine-induced mild hepatotoxicity.
• Impact of CYP2D6*10 on H1-antihistamine-induced hypersomnia.
• In Situ Detection of Surface SiH(n) in Synchrotron-Radiation-Induced Chemical Vapor Deposition of a-Si on an SiO(2) Substrate.
• Interfacility transport of the critically ill pediatric patient.
• New Secoiridoid Glucosides from Ligustrum japonicum.
• Nuclear translocation of ADAM-10 contributes to the pathogenesis and progression of human prostate cancer.
• Overexpression of RGPR-p117 suppresses apoptotic cell death and its related gene expression in cloned normal rat kidney proximal tubular epithelial NRK52E cells.
• Pulse radiolysis study on free radical scavenger edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one).
• Rectified momentum transport for a kicked Bose-Einstein condensate.
• TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection.
• The mRNA-like noncoding RNA Gomafu constitutes a novel nuclear domain in a subset of neurons.
• Thiazide diuretics exacerbate fructose-induced metabolic syndrome.
• Uncoupling of the VEGF-endothelial nitric oxide axis in diabetic nephropathy: an explanation for the paradoxical effects of VEGF in renal disease.
• [A patient with small cerebellar infarcts at tonsil and nodulus who complained of vertigo, vomiting and chest oppression]
• [Biological characteristics of an established model of ovarian cancer in mice and its homologous cell lines]
• [Coronary artery aneurysm]
• [Myocardial infarction in young patients]
• [Position of NSAIDs in causal factors of peptic ulcer]