Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006.

Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Research Abstract Details 

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Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Abstract Text:

S Fukuda,M Ishikawa,N Ochiai,Y Suzuki,J Sunaga,N Shinohara,K Nozawa,F Tsuda,M Takahashi,H Okamoto,

Hepatitis E is rare in Japan but is occurring more frequently than previously thought. To investigate whether de novo subclinical infection of hepatitis E virus (HEV) has recently increased in Japan, HEV RNA was assayed in serum samples obtained from 4019 Japanese voluntary blood donors with alanine aminotransferase (ALT) of > or =61 IU/l, who are likely to have ongoing HEV infection, during 1991-2006. The overall rates of IgG-class antibody to HEV (anti-HEV IgG), anti-HEV IgM/IgA and HEV RNA among 3185 donors in 2004-2006 were comparable with those among 594 donors in 1998 (5.3 vs. 5.2%, 0.2 vs. 0.5%, and 0.2 vs. 0.3%, respectively). Among blood donors with ALT > or = 201 IU/l in three groups according to the year of blood collection (1991-1995 [n = 156], 1996-1999 [n = 116] and 2004-2006 [n = 61]), there were no appreciable differences in the prevalence of anti-HEV IgG (5.8, 4.3, and 6.6%, respectively), anti-HEV IgM/IgA (1.9, 3.4, and 3.3%, respectively) and HEV RNA (1.3, 3.4, and 3.3%, respectively). The eleven HEV isolates obtained in the present study differed from each other by 1.7-22.8% in the ORF2 sequence and segregated into genotype 3 or 4. The occurrence rate of subclinical infection with divergent HEV strains has essentially remained unchanged during 1991-2006 in Japan.

Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Publishing Authors By Initials

S Fukuda,M Ishikawa,N Ochiai,Y Suzuki,J Sunaga,N Shinohara,K Nozawa,F Tsuda,M Takahashi,H Okamoto,

For similar reproductive and urinary physiology: reproduction: sex characteristics research abstracts see: reproductive and urinary physiology: reproduction: sex characteristics research

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Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of virology

VOLUME: 152

Page Numbers: 1623-35

Journal Abbreviation: Arch. Virol.

ISSN: 0304-8608

DAY: 29

MONTH: 05

YEAR: 2007

Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7506870

Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Keywords Mesh Terms:

KEYWORDS: Sex Characteristics

MESH TERMS: genetics

Chemical & Substance for Abstract: Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006. Information

Substance Name: Alanine Transaminase

Registry Number: EC 2.6.1.2

Grant and Affiliation Information for Unchanged high prevalence of antibodies to hepatitis E virus (HEV) and HEV RNA among blood donors with an elevated alanine aminotransferase level in Japan during 1991-2006.

AFFILIATION: Japanese Red Cross Tochigi Blood Center, Tochigi, Japan.

Country: Austria

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MEDLINETA: Arch Virol

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ACCESSION NUMBER: AB292659

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