Uncertainty in BRCA1 cancer susceptibility testing.

Uncertainty in BRCA1 cancer susceptibility testing. Research Abstract Details 

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Uncertainty in BRCA1 cancer susceptibility testing. Abstract Text:

Bonnie J Baty,William N Dudley,Adrian Musters,Anita Y Kinney,

This study investigated uncertainty in individuals undergoing genetic counseling/testing for breast/ovarian cancer susceptibility. Sixty-three individuals from a single kindred with a known BRCA1 mutation rated uncertainty about 12 items on a five-point Likert scale before and 1 month after genetic counseling/testing. Factor analysis identified a five-item total uncertainty scale that was sensitive to changes before and after testing. The items in the scale were related to uncertainty about obtaining health care, positive changes after testing, and coping well with results. The majority of participants (76%) rated reducing uncertainty as an important reason for genetic testing. The importance of reducing uncertainty was stable across time and unrelated to anxiety or demographics. Yet, at baseline, total uncertainty was low and decreased after genetic counseling/testing (P = 0.004). Analysis of individual items showed that after genetic counseling/testing, there was less uncertainty about the participant detecting cancer early (P = 0.005) and coping well with their result (P < 0.001). Our findings support the importance to clients of genetic counseling/testing as a means of reducing uncertainty. Testing may help clients to reduce the uncertainty about items they can control, and it may be important to differentiate the sources of uncertainty that are more or less controllable. Genetic counselors can help clients by providing anticipatory guidance about the role of uncertainty in genetic testing.

Uncertainty in BRCA1 cancer susceptibility testing. Publishing Authors By Initials

BJ Baty,WN Dudley,A Musters,AY Kinney,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: uncertainty research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: uncertainty research

PUBMED ID PMID:

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Uncertainty in BRCA1 cancer susceptibility testing. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of medical genetics. Part C, Semi

VOLUME: 142

Page Numbers: 241-50

Journal Abbreviation:

ISSN: 1552-4868

DAY: 15

MONTH: Nov

YEAR: 2006

Uncertainty in BRCA1 cancer susceptibility testing. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101235745

Uncertainty in BRCA1 cancer susceptibility testing. Keywords Mesh Terms:

KEYWORDS: Uncertainty

MESH TERMS: psychology

Chemical & Substance for Abstract: Uncertainty in BRCA1 cancer susceptibility testing. Information

Substance Name: BRCA1 Protein

Registry Number: 0

Grant and Affiliation Information for Uncertainty in BRCA1 cancer susceptibility testing.

AFFILIATION: Graduate Program in Genetic Counseling, Division of Medical Genetics, University of Utah Health Science Center, Salt Lake City, UT 84132, USA. bonnie.baty@hsc.utah.edu

Country: United States

AGENCY: United States NHGRI

GRANT: R01 HG 02241-02

ACRONYM: HG

MEDLINETA: Am J Med Genet C Semin Med Gen

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