Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury.

Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Research Abstract Details 

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Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Abstract Text:

Venkata Ramesh Dasari,Daniel G Spomar,Liang Li,Meena Gujrati,Jasti S Rao,Dzung H Dinh,Venkata Ramesh Dasari,Daniel G Spomar,Liang Li,Meena Gujrati,Jasti S Rao,Dzung H Dinh,Venkata Ramesh Dasari,Daniel G Spomar,Liang Li,Meena Gujrati,Jasti S Rao,Dzung H Dinh,

Human umbilical cord blood stem cells (hUCB), due to their primitive nature and ability to develop into nonhematopoietic cells of various tissue lineages, represent a potentially useful source for cell-based therapies after spinal cord injury (SCI). To evaluate their therapeutic potential, hUCB were stereotactically transplanted into the injury epicenter, one week after SCI in rats. Our results show the presence of a substantial number of surviving hUCB in the injured spinal cord up to five weeks after transplantation. Three weeks after SCI, apoptotic cells were found especially in the dorsal white matter and gray matter, which are positive for both neuron and oligodendrocyte markers. Expression of Fas on both neurons and oligodendrocytes was efficiently downregulated by hUCB. This ultimately resulted in downregulation of caspase-3 extrinsic pathway proteins involving increased expression of FLIP, XIAP and inhibition of PARP cleavage. In hUCB-treated rats, the PI3K/Akt pathway was also involved in antiapoptotic actions. Further, structural integrity of the cytoskeletal proteins alpha-tubulin, MAP2A&2B and NF-200 has been preserved in hUCB treatments. The behavioral scores of hind limbs of hUCB-treated rats improved significantly than those of the injured group, showing functional recovery. Taken together, our results indicate that hUCB-mediated downregulation of Fas and caspases leads to functional recovery of hind limbs of rats after SCI.

Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Publishing Authors By Initials

VR Dasari,DG Spomar,L Li,M Gujrati,JS Rao,DH Dinh,VR Dasari,DG Spomar,L Li,M Gujrati,JS Rao,DH Dinh,VR Dasari,DG Spomar,L Li,M Gujrati,JS Rao,DH Dinh,

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Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemical research

VOLUME: 33

Page Numbers: 134-49

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 17

MONTH: 08

YEAR: 2007

Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury. Information

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LANGUAGE: eng

NlmUniqueID: 7613461

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Grant and Affiliation Information for Umbilical cord blood stem cell mediated downregulation of fas improves functional recovery of rats after spinal cord injury.

AFFILIATION: Department of Cancer Biology and Pharmacology, University of Illinois College of Medicine, Peoria, IL, 61656, USA.

Country: United States

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MEDLINETA: Neurochem Res

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