Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly.

Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Research Abstract Details 

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Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Abstract Text:

A M Landolt,U Ryffel,H U Hosbach,R Wyler,

Tubular inclusions were present in 13 out of 43 pituitary adenomas of acromegalic patients and in a single chromophobe pituitary adenoma. There were none in 76 other pituitary adenomas with differing endocrinological symptomatology. The arrays were usually located in the perinuclear cistern of capillary endothelial cells. The tubule diameter in osmium fixed material measured 19-26 nm and the light core averaged 6-11 nm. A longitudinal period of about 4.5 nm could be demonstrated with PTA block staining. Fixation with glutaraldehyde and block staining with ethidium bromide as well as permanganate fixation followed by RNAse treatment showed only the core of the tubules consisting of globular subunits. Several histochemical reactions (perchloric acid extraction, methenamine-silver staining, trypsin and DNAse digestion of frozen sections) suggested that the particles consist of a core of DNA coated with protein. No virus multiplication could be detected in cell cultures or in mice innoculated with fresh tumor material. No significant antibody titers against several virus antigens could be demonstrated.

Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Publishing Authors By Initials

AM Landolt,U Ryffel,HU Hosbach,R Wyler,

For similar neoplasms: neoplasms by site: endocrine gland neoplasms: pituitary neoplasms research abstracts see: neoplasms: neoplasms by site: endocrine gland neoplasms: pituitary neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Virchows Archiv. A, Pathological anatomy and histo

VOLUME: 370

Page Numbers: 129-40

Journal Abbreviation:

ISSN: 0340-1227

DAY: 3

MONTH: May

YEAR: 1976

Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505137

Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Keywords Mesh Terms:

KEYWORDS: Pituitary Neoplasms

MESH TERMS: pathology

Chemical & Substance for Abstract: Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly. Information

Substance Name: DNA, Neoplasm

Registry Number: 0

Grant and Affiliation Information for Ultrastructure of tubular inclusions in endothelial cells of pituitary tumors associated with acromegaly.

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Country: GERMANY, WEST

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MEDLINETA: Virchows Arch A Pathol Anat Hi

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