Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils.

Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils. Research Abstract Details 

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Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils. Abstract Text:

Koichi Kato,Hideki Sato,Hiroo Iwata,Koichi Kato,Hideki Sato,Hiroo Iwata,Koichi Kato,Hideki Sato,Hiroo Iwata,

In an attempt to develop collagen-growth factor composites for use in tissue engineering, chimeric proteins consisting of epidermal growth factor and collagen binding domains derived from von Willebrand factor or fibronectin were synthesized by means of recombinant technology. These chimeric proteins were bound to type I collagen fibrils, and the ultrastructures of composites were analyzed by transmission electron microscopy combined with the gold nanoparticle labeling technique. The results of the ultrastructural study revealed that chimeric proteins were densely assembled on collagen fibrils through the specific recognition of binding sites, producing the ordered array of chimeric proteins.

Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils. Publishing Authors By Initials

K Kato,H Sato,H Iwata,K Kato,H Sato,H Iwata,K Kato,H Sato,H Iwata,

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Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioconjugate chemistry

VOLUME: 18

Page Numbers: 2137-43

Journal Abbreviation: Bioconjug. Chem.

ISSN: 1043-1802

DAY: 26

MONTH: 09

YEAR: 2007

Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils. Information

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LANGUAGE: eng

NlmUniqueID: 9010319

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Grant and Affiliation Information for Ultrastructural study on the specific binding of genetically engineered epidermal growth factor to type I collagen fibrils.

AFFILIATION: iwata@frontier.kyoto-u.ac.jp.

Country: United States

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MEDLINETA: Bioconjug Chem

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