Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling.

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Research Abstract Details 

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Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Abstract Text:

Marie Anne O'Donnell,Diana Legarda-Addison,Penelopi Skountzos,Wen Chen Yeh,Adrian T Ting,

TNF receptor 1 (TNFR1) can trigger opposing responses within the same cell: a prosurvival response or a cell-death pathway [1, 2]. Cell survival requires NF-kappaB-mediated transcription of prosurvival genes [3-9]; apoptosis occurs if NF-kappaB signaling is blocked [5, 7-9]. Hence, activation of NF-kappaB acts as a cell-death switch during TNF signaling. This study demonstrates that the pathway includes another cell-death switch that is independent of NF-kappaB. We show that lysine 63-linked ubiquitination of RIP1 on lysine 377 inhibits TNF-induced apoptosis first through an NF-kappaB-independent mechanism and, subsequently, through an NF-kappaB-dependent mechanism. In contrast, in the absence of ubiquitination, RIP1 serves as a proapoptotic signaling molecule by engaging CASPASE-8. Therefore, RIP1 is a dual-function molecule that can be either prosurvival or prodeath depending on its ubiquitination state, and this serves as an NF-kappaB-independent cell-death switch early in TNF signaling. These results provide an explanation for the conflicting reports on the role of RIP1 in cell death; this role was previously suggested to be both prosurvival and prodeath [10-12]. Because TRAF2 is the E3 ligase for RIP1 [13], these observations provide an explanation for the NF-kappaB-independent antiapoptotic function previously described for TRAF2 [14-16].

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Publishing Authors By Initials

MA O'Donnell,D Legarda-Addison,P Skountzos,WC Yeh,AT Ting,

For similar proteins: ubiquitins research abstracts see: proteins: ubiquitins research

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Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 418-24

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 15

MONTH: 02

YEAR: 2007

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107782

Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Keywords Mesh Terms:

KEYWORDS: Ubiquitins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling. Information

Substance Name: Receptor-Interacting Protein Serine-Thre

Registry Number: EC 2.7.1.37

Grant and Affiliation Information for Ubiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signaling.

AFFILIATION: Immunobiology Center, Mount Sinai School of Medicine, Box 1630, One Gustave L. Levy Place, New York, NY 10029, USA.

Country: England

AGENCY: United States NIAID

GRANT: R21 AI057997-02

ACRONYM: AI

MEDLINETA: Curr Biol

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