Ubiquitin system: selectivity and timing of protein destruction.

Ubiquitin system: selectivity and timing of protein destruction. Research Abstract Details 

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Ubiquitin system: selectivity and timing of protein destruction. Abstract Text:

F Yamao,

A growing number of cellular functions have been shown to be regulated through protein degradation. The selective degradation of many short-lived proteins in eukaryotic cells is mediated by the ubiquitin system, by which proteins covalently ligated to ubiquitin are targeted for degradation. The selectivity of the destruction is ensured by the substrate specificity in the ubiquitination steps composed of a series of enzymatic reactions. Ubiquitin-ligase (E3), in conjunction with ubiquitin-conjugating enzyme (E2), has been implicated as playing an essential role in the substrate recognition. The substantial character, however, of the ligase was not clear until several recent studies demonstrated ligases that exert key roles in irreversible steps of the cell-cycle control. In this review, attention is focused on the molecular basis of target recognition of ubiquitination, particularly as exemplified in the ubiquitin-ligases in the cell-cycle control mechanisms.

Ubiquitin system: selectivity and timing of protein destruction. Publishing Authors By Initials

F Yamao,

For similar proteins: ubiquitins research abstracts see: proteins: ubiquitins research

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Ubiquitin system: selectivity and timing of protein destruction. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of biochemistry

VOLUME: 125

Page Numbers: 223-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Feb

YEAR: 1999

Ubiquitin system: selectivity and timing of protein destruction. Information

Number of References: 48

LANGUAGE: eng

NlmUniqueID: 376600

Ubiquitin system: selectivity and timing of protein destruction. Keywords Mesh Terms:

KEYWORDS: Ubiquitins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ubiquitin system: selectivity and timing of protein destruction. Information

Substance Name: anaphase-promoting complex

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Ubiquitin system: selectivity and timing of protein destruction.

AFFILIATION: Laboratory of Mutagenesis, Department of Molecular Genetics, National Institute of Genetics, Mishima, 411-8540, Japan. fyamao@lab. nig.ac.jp

Country: JAPAN

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MEDLINETA: J Biochem

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