Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Research Abstract Details 

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Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Abstract Text:

Yang Kang,Naixia Zhang,Deanna M Koepp,Kylie J Walters,

Ubiquitin receptor proteins play an important role in delivering ubiquitylated protein substrates to the proteasome for degradation. HHR23a and hPLIC2 are two such ubiquitin receptors that contain ubiquitin-like (UBL) domains, which interact with the proteasome, and ubiquitin-associated (UBA) domains, which interact with ubiquitin. Depending on their abundance UBL/UBA family members can either promote or inhibit the degradation of other proteins, which suggests their participation in the delivery of substrates to the proteasome is highly regulated. In previous work, we determined UBL/UBA domain interactions to promote intramolecular interactions in hHR23a that are abrogated with the addition of either ubiquitin or the proteasome component S5a. In yeast, we determined the hHR23a ortholog (Rad23) to interact with another UBL/UBA family member (Ddi1) and to bind a common tetraubiquitin chain. Here, we use NMR spectroscopy to reveal that hHR23a interacts with hPLIC2 via UBL/UBA domain interactions and to map their binding surfaces. In addition, we demonstrate that these two proteins associate in mammalian cells. Intriguingly, inhibition of the proteasome mitigates hHR23a/hPLIC2 interaction.

Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Publishing Authors By Initials

Y Kang,N Zhang,DM Koepp,KJ Walters,

For similar proteins: ubiquitins research abstracts see: proteins: ubiquitins research

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Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of molecular biology

VOLUME: 365

Page Numbers: 1093-101

Journal Abbreviation: J. Mol. Biol.

ISSN: 0022-2836

DAY: 21

MONTH: 10

YEAR: 2006

Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985088

Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Keywords Mesh Terms:

KEYWORDS: Ubiquitins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ubiquitin receptor proteins hHR23a and hPLIC2 interact. Information

Substance Name: Proteasome Endopeptidase Complex

Registry Number: EC 3.4.25.1

Grant and Affiliation Information for Ubiquitin receptor proteins hHR23a and hPLIC2 interact.

AFFILIATION: Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.

Country: England

AGENCY: United States NCI

GRANT: R01 CA097004-04

ACRONYM: CA

MEDLINETA: J Mol Biol

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