Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Research Abstract Details 

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Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Abstract Text:

Toru Fukushima,Shu-ichi Matsuzawa,Christina L Kress,Jean Marie Bruey,Maryla Krajewska,Sophie Lefebvre,Juan M Zapata,Ze'ev Ronai,John C Reed,

Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity. Gene ablation was used to study the function of Ubc13 in mice. Whereas homozygous ubc13 gene disruption resulted in embryonic lethality, heterozygous ubc13(+/-) mice appeared normal, without alterations in immune cell populations. Haploinsufficient ubc13(+/-) mice were resistant to lipopolysaccharide-induced lethality, and demonstrated reduced in vivo ubiquitination of TRAF6. Macrophages and splenocytes isolated from ubc13(+/-) mice exhibited reduced lipopolysaccharide-inducible cytokine secretion and impaired activation of TRAF-dependent signal transduction pathways (NF-kappaB, JNK, and p38 MAPK). These findings document a critical role for Ubc13 in inflammatory responses and suggest that agents reducing Ubc13 activity could have therapeutic utility.

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Publishing Authors By Initials

T Fukushima,S Matsuzawa,CL Kress,JM Bruey,M Krajewska,S Lefebvre,JM Zapata,Z Ronai,JC Reed,

For similar enzymes and coenzymes: enzymes: ligases: ubiquitin-protein ligase complexes: ubiquitin-conjugating enzymes research abstracts see: enzymes and coenzymes: enzymes: ligases: ubiquitin-protein ligase complexes: ubiquitin-conjugating enzymes research

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Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 6371-6

Journal Abbreviation:

ISSN: 0027-8424

DAY: 2

MONTH: 04

YEAR: 2007

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Keywords Mesh Terms:

KEYWORDS: Ubiquitin-Conjugating Enzymes

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses. Information

Substance Name: Ubiquitin-Conjugating Enzymes

Registry Number: EC 6.3.2.19

Grant and Affiliation Information for Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses.

AFFILIATION: Burnham Institute for Medical Research, La Jolla, CA 92037, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA69381

ACRONYM: CA

MEDLINETA: Proc Natl Acad Sci U S A

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