Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.

Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Research Abstract Details 

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Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Abstract Text:

Hongmin Wang,Mervyn J Monteiro,

Previously, we showed that overexpression of ubiquilin reduces protein aggregates and toxicity of expanded polyglutamine proteins. Here, we investigated the mechanism of ubiquilin's protective effect. Immunofluorescence microscopy and immunoprecipitation studies indicated that ubiquilin colocalized and coimmunoprecipitated more with GFP-huntingtin-exon-1-fusion proteins containing a 74-polyglutamine tract than with GFP-huntingtin-fusion proteins containing a 28-polyglutamine tract or with GFP protein alone. Furthermore, overexpression of ubiquilin selectively enhanced the turnover of the expanded GFP-huntingtin-fusion protein. These results suggest that elevating ubiquilin levels could aid in the selective disposal of potentially toxic expanded polyglutamine proteins that are thought to cause several human diseases.

Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Publishing Authors By Initials

H Wang,MJ Monteiro,

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Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Biochemical and biophysical research communication

VOLUME: 360

Page Numbers: 423-7

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 25

MONTH: 06

YEAR: 2007

Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Keywords Mesh Terms:

KEYWORDS: Peptides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins. Information

Substance Name: polyglutamine

Registry Number: 26700-71-0

Grant and Affiliation Information for Ubiquilin interacts and enhances the degradation of expanded-polyglutamine proteins.

AFFILIATION: Institute for Neurodegenerative Diseases, Medical Biotechnology Center, University of Maryland Biotechnology Institute, Baltimore, MD 21201, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM066287

ACRONYM: GM

MEDLINETA: Biochem Biophys Res Commun

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