Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates.

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Abstract Text:

Meztli D Arguello,John Hiscott,Meztli D Arguello,John Hiscott,Meztli D Arguello,John Hiscott,

Conjugation of ubiquitin regulates multiple pathways, including the signaling cascades leading to antiviral immunity. Similarly, the ubiquitin-like peptide ISG15 mediates the antiviral response to certain viruses. In this issue of Cell Host & Microbe, Frias-Staheli and colleagues demonstrate that research on viral proteases of certain nairoviruses and arteriviruses reveals the presence of ovarian tumor domain-containing sequences that act as general deubiquitinases and deISGylases and increase viral replication by inhibiting the antiviral response mediated by ISG15.

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Publishing Authors By Initials

MD Arguello,J Hiscott,MD Arguello,J Hiscott,MD Arguello,J Hiscott,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell host & microbe

VOLUME: 2

Page Numbers: 367-9

Journal Abbreviation: Cell Host Microbe

ISSN: 1934-6069

DAY: 13

MONTH: Dec

YEAR: 2007

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101302316

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates.

AFFILIATION: Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal H3T 1E2, Canada.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Cell Host Microbe

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates Related Publications

• Chemical targeting of the innate antiviral response by histone deacetylase inhibitors renders refractory cancers sensitive to viral oncolysis.
• Convergence of the NF-kappaB and IRF pathways in the regulation of the innate antiviral response.
• Cytokeratin subtyping to distinguish reactive and neoplastic RPE cells.
• Health services in four isolated districts in Nova Scotia.
• Histological findings of a choroidal neovascular membrane removed at the time of macular translocation in a patient previously treated with intravitreal bevacizumab treatment (Avastin).
• Human papillomavirus in pterygium.
• Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20.
• Neoplastic transformation of ciliary body epithelium is associated with loss of opticin expression.
• RIG-I has guts: identification of a role for RIG-I in colitis development.
• SDF1-alpha is associated with VEGFR-2 in human choroidal neovascularisation.
• Targeting the apoptotic pathway with BCL-2 inhibitors sensitizes primary chronic lymphocytic leukemia cells to vesicular stomatitis virus-induced oncolysis.
• Temporal pterygium: benign or not?
• Ub Surprised: Viral Ovarian Tumor Domain Proteases Remove Ubiquitin and ISG15 Conjugates.
• Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation.