U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia.

U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Research Abstract Details 

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U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Abstract Text:

W Xiao,Q Zhang,G Habermacher,X Yang,A-Y Zhang,X Cai,J Hahn,J Liu,M Pins,L Doglio,R Dhir,J Gingrich,Z Wang,

Upregulated gene 19 (U19)/ELL-associated factor 2 (Eaf2) is a potential human tumor suppressor that exhibits frequent allelic loss and downregulation in high-grade prostate cancer. U19/Eaf2, along with its homolog Eaf1, has been reported to regulate transcriptional elongation via interaction with the eleven-nineteen lysine-rich leukemia (ELL) family of proteins. To further explore the tumor-suppressive effects of U19/Eaf2, we constructed and characterized a murine U19/Eaf2-knockout model. Homozygous or heterozygous deletion of U19/Eaf2 resulted in high rates of lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostate intraepithelial neoplasia. Within the mouse prostate, U19/Eaf2 deficiency enhanced cell proliferation and increased epithelial cell size. The knockout mice also exhibited cardiac cell hypertrophy. These data indicate a role for U19/Eaf2 in growth suppression and cell size control as well as argue for U19/Eaf2 as a novel tumor suppressor in multiple mouse tissues. The U19/Eaf2 knockout mouse also provides a unique animal model for three important cancers: lung adenocarcinoma, B-cell lymphoma and hepatocellular carcinoma.Oncogene (2008) 27, 1536-1544; doi:10.1038/sj.onc.1210786; published online 17 September 2007.

U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Publishing Authors By Initials

W Xiao,Q Zhang,G Habermacher,X Yang,AY Zhang,X Cai,J Hahn,J Liu,M Pins,L Doglio,R Dhir,J Gingrich,Z Wang,

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U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Oncogene

VOLUME: 27

Page Numbers: 1536-44

Journal Abbreviation: Oncogene

ISSN: 1476-5594

DAY: 17

MONTH: 09

YEAR: 2007

U19/Eaf2 knockout causes lung adenocarcinoma, B-cell lymphoma, hepatocellular carcinoma and prostatic intraepithelial neoplasia. Information

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LANGUAGE: eng

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AFFILIATION: [1] 1Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA [2] 2Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, PR China.

Country: England

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MEDLINETA: Oncogene

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