Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease.

Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Research Abstract Details 

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Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Abstract Text:

Post-translational sulfation of tyrosines affects the affinity and binding of at least some chemokine receptors to their ligand(s) and has been hypothesized to be a feature in all chemokine receptors. This binding initiates downstream signaling cascades. By this mechanism, tyrosine sulfation can influence the cells involved in acute and chronic events of cellular immunity. These events include leukocyte trafficking and airway inflammation important in asthma and chronic obstructive pulmonary disease (COPD). We are using computational methods to convert the poorly defined hypothesis of more widespread sulfation of chemokine receptors to more specific assessments of how closely the sequence environment of each tyrosine residue resembles the sequence environment of tyrosine residues proven to be sulfated. Thus, we provide specific and readily tested hypotheses about the tyrosine residues in all of the chemokine receptors. Tyrosine sulfation was predicted with high scores in the N-terminus domain of 13 out of 18 human chemokine receptor proteins using a position-specific scoring matrix, which was determined to be 94.2% accurate based on Receiver Operating Characteristic analysis. The remaining chemokine receptors have sites exhibiting features of tyrosine sulfation. These putative sites demonstrate clustering in a manner consistent with known tyrosine sulfation sites and conservation both within the chemokine receptor family and across mammalian species. Human chemokine receptors important in asthma and COPD, such as CXCR1, CXCR2, CXCR3, CXCR4, CCR1, CCR2, CCR3, CCR4, CCR5, and CCR8, contain at least one known or predicted tyrosine sulfation site. Recognition that tyrosine sulfation is found in most clinically relevant chemokine receptors could help the development of specific receptor-ligand antagonists to modulate events important in airway diseases.

Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Publishing Authors By Initials

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Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: American journal of respiratory cell and molecular

VOLUME: 38

Page Numbers: 738-43

Journal Abbreviation: Am. J. Respir. Cell Mol. Biol.

ISSN: 1535-4989

DAY: 24

MONTH: 01

YEAR: 2008

Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease. Information

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LANGUAGE: eng

NlmUniqueID: 8917225

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Grant and Affiliation Information for Tyrosine sulfation is prevalent in human chemokine receptors important in lung disease.

AFFILIATION: Section of Neurobiology, Physiology and Behavior, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA.

Country: United States

AGENCY: United States NCRR

GRANT: RR06009

ACRONYM: RR

MEDLINETA: Am J Respir Cell Mol Biol

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