Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin.

Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Research Abstract Details 

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Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Abstract Text:

White forelock and hypomelanotic macules of piebaldism have been revealed to have almost regularly distributed, dopa-positive melanocytes, though with lower density than normal, on separated epidermis despite previous reports describing few or no melanocytes in piebald spots. The melanocytes observed in piebald hypomelanotic spots seem to be classified into the following two types: (1) strongly dopa-positive and markedly hyperdendritic large cell type and (2) moderately dopa-positive and slightly hyperdendritic, oversized cell type. The former are primarily seen in hypomelanotic lesions, while the latter are seen in transitional lesions. The above difference seems to be associated with compensatory melanogenic function of melanocytes in vivo. Moreover, we have induced new hyperpigmented spots in hypomelanotic lesions, with the exception of white forelock, following therapy with oral methoxsalen plus ultraviolet A light.

Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Publishing Authors By Initials

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Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Archives of dermatology

VOLUME: 124

Page Numbers: 381-6

Journal Abbreviation: Arch Dermatol

ISSN: 0003-987X

DAY: 17

MONTH: Mar

YEAR: 1988

Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Information

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LANGUAGE: eng

NlmUniqueID: 372433

Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: pathology

Chemical & Substance for Abstract: Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin. Information

Substance Name: Monophenol Monooxygenase

Registry Number: EC 1.14.18.1

Grant and Affiliation Information for Tyrosinase-positive melanocyte distribution and induction of pigmentation in human piebald skin.

AFFILIATION: Department of Dermatology, Kobe (Japan) University School of Medicine.

Country: UNITED STATES

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MEDLINETA: Arch Dermatol

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