Type XXVII collagen at the transition of cartilage to bone during skeletogenesis.

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Abstract Text:

Rebecca Hjorten,Uwe Hansen,Robert A Underwood,Helena E Telfer,Russell J Fernandes,Deborah Krakow,Eiman Sebald,Sebastian Wachsmann-Hogiu,Peter Bruckner,Robin Jacquet,William J Landis,Peter H Byers,James M Pace,

COL27A1 is a member of the collagen fibrillar gene family and is expressed in cartilaginous tissues including the anlage of endochondral bone. To begin to understand its role in skeletogenesis, the temporospatial distributions of its RNA message and protein product, type XXVII collagen, were determined in developing human skeletal tissues. Laser capture microdissection and quantitative reverse-transcription polymerase chain reaction demonstrated that gene expression occurred throughout the growth plate and that it was higher in the resting and proliferative zones than in hypertrophic cartilage. Immunohistochemical analyses showed that type XXVII collagen was most evident in hypertrophic cartilage at the primary ossification center and at the growth plate and that it accumulated in the pericellular matrix. Synthesis of type XXVII collagen overlapped partly with that of type X collagen, a marker of chondrocyte hypertrophy, preceded the transition of cartilage to bone, and was associated with cartilage calcification. Immunogold electron microscopy of extracted ECM components from mouse growth plate showed that type XXVII collagen was a component of long non-banded fibrous structures, filamentous networks, and thin banded fibrils. The timing and location of synthesis suggest that type XXVII collagen plays a role during the calcification of cartilage and the transition of cartilage to bone.

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Publishing Authors By Initials

R Hjorten,U Hansen,RA Underwood,HE Telfer,RJ Fernandes,D Krakow,E Sebald,S Wachsmann-Hogiu,P Bruckner,R Jacquet,WJ Landis,PH Byers,JM Pace,

For similar musculoskeletal system: skeleton research abstracts see: musculoskeletal system: skeleton research

PUBMED ID PMID:

MEDLINE DATE:

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bone

VOLUME: 41

Page Numbers: 535-42

Journal Abbreviation: Bone

ISSN: 8756-3282

DAY: 13

MONTH: 07

YEAR: 2007

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8504048

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Keywords Mesh Terms:

KEYWORDS: Skeleton

MESH TERMS: genetics

Chemical & Substance for Abstract: Type XXVII collagen at the transition of cartilage to bone during skeletogenesis. Information

Substance Name: RNA, Messenger

Registry Number: 0

Grant and Affiliation Information for Type XXVII collagen at the transition of cartilage to bone during skeletogenesis.

AFFILIATION: Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Country: United States

AGENCY: United States NICHD

GRANT: HD22567

ACRONYM: HD

MEDLINETA: Bone

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Type XXVII collagen at the transition of cartilage to bone during skeletogenesis Related Publications

• Acne in adult women.
• Amino acid contribution to protein solubility: Asp, Glu, and Ser contribute more favorably than the other hydrophilic amino acids in RNase Sa.
• An algorithm for separating multilevel random telegraph signal from 1f noise.
• An association between negatively biased response to neutral stimuli and antidepressant nonadherence.
• Colloidal bismuth subcitrate and two different dosages of cimetidine in the treatment of resistant duodenal ulcer. Preliminary results.
• Ectopic hydroureter.
• Effects of atomic bomb radiations on human food.
• Endolithic microbial ecosystems.
• Eucaryotic diversity in a hypersaline microbial mat.
• Fluid management in patients on hemodialysis.
• Gastrointestinal microbiology enters the metagenomics era.
• Increasing protein conformational stability by optimizing beta-turn sequence.
• Innovations in oesophageal function testing.
• Leading indicators of trophic cascades.
• Maintaining access to safe abortion in the United States: a post-Gonzales primer and guide to action.
• Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.
• Microbial community biofabrics in a geothermal mine adit.
• Molecular identification of bacteria in bronchoalveolar lavage fluid from children with cystic fibrosis.
• Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases.
• Nonignorable covariates.
• Peptide sequence and conformation strongly influence tryptophan fluorescence.
• Potential options to optimize therapy of gastroesophageal reflux disease with proton pump inhibitors.
• Preservation of the ischemic canine myocardium: a comparison of hypothermia, lidoflazine, and ketanserin.
• Stopping the error cascade: a report on ameliorators from the ASIPS collaborative.
• The use of metallic glass scroll as an acoustic transducer element.
• Tryptophan fluorescence reveals the presence of long-range interactions in the denatured state of ribonuclease Sa.
• Type XXVII collagen at the transition of cartilage to bone during skeletogenesis.
• [A new questionnaire for evaluation of GERD symptoms. GERD Impacte Scale]
• [Integrated therapeutic strategy in large bowel neoplastic occlusion. An innovative therapeutic protocol]
• [Malignant endocrine exophthalmos; clinical & etiopathogenic study of a case of monolateral progressive edematous exophthalmos.]