Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells.

Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Research Abstract Details 

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Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Abstract Text:

Tomonari Katayama,Kazuaki Nakanishi,Hiroshi Nishihara,Naoya Kamiyama,Takahito Nakagawa,Toshiya Kamiyama,Ken Iseki,Shinya Tanaka,Satoru Todo,

Type I interferon (IFN) was originally identified as an immunomodulatory cytokine because of its antiviral activity. Further characterization of its biological effects revealed a prominent role in the direct control of cell growth and potent immunomodulatory and antiangiogenic actions. IFN-alpha and IFN-beta had both been classified as type I IFN, but differences in their antitumor activities were reported. We confirmed the difference in the antiproliferative activities of IFN-alpha2b and IFN-beta toward HT29 and SW480 cells. IFN treatment was observed to prolong cell cycle progression; in particular, the accumulation of S-phase population was one of the most characteristic changes. The prolongation of S-phase progression and transition into G2/M-phase was suggested to be a crucial action of type I IFN on colon cancer. Additionally, IFN activated the p21 promoter gene and induced p21WAF1/CIP1 expression. Furthermore, the cell cycle prolongation effect of IFN was suppressed when p21 expression was downregulated. Therefore, we confirmed that p21WAF1/CIP1 was a crucial target molecule for the effects of IFN on the cell cycle. Additionally, the ability of p21 induction differed between IFN-alpha2b and IFN-beta and correlated with their inhibitory activities toward cell growth. We conclude that type I IFN prolongs cell cycle progression by p21WAF1/CIP1 induction in human colon cancer cells.

Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Publishing Authors By Initials

T Katayama,K Nakanishi,H Nishihara,N Kamiyama,T Nakagawa,T Kamiyama,K Iseki,S Tanaka,S Todo,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell cycle: interphase: s phase research

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Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of oncology

VOLUME: 31

Page Numbers: 613-20

Journal Abbreviation: Int. J. Oncol.

ISSN: 1019-6439

DAY: 30

MONTH: Sep

YEAR: 2007

Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9306042

Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Keywords Mesh Terms:

KEYWORDS: S Phase

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells. Information

Substance Name: Interferon Alfa-2b

Registry Number: 99210-65-8

Grant and Affiliation Information for Type I interferon prolongs cell cycle progression via p21WAF1/CIP1 induction in human colon cancer cells.

AFFILIATION: Department of General Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. tomonari@f4.dion.ne.jp

Country: Greece

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MEDLINETA: Int J Oncol

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