Two-stage kinetic analysis of fragrance evaporation and absorption from skin.

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Abstract Text:

Human in vivo fragrance evaporation data from a previously published study are reanalysed in terms of compartmental pharmacokinetic models in which the microscopic rate constants are functions of the physicochemical properties of the fragrance components. According to the proposed analysis, which is restricted to low doses, absorption and evaporation of each component are first-order processes occurring from either the skin (one-compartment model) or the skin and a more rapidly depleted vehicle layer (two-compartment models). Evaporation rates of ingredients from a 12-component mixture containing a musk fixative followed single exponential decays that were well described by the one-compartment model. An otherwise identical mixture without fixative yielded evaporation rates that could be characterized as biexponential decays associated with loss from two compartments. This result shows that ingredient interactions qualitatively and quantitatively change evaporation rate profiles of fragrance components; however, an attempt to account for these interactions explicitly by means of activity coefficients inserted as multipliers for the microscopic rate constants was unsuccessful. Re-examination of this approach in the context of a diffusion/evaporation model is suggested. The developed models have potential utility for dermal risk assessment and for prediction of aroma evolution following topical application of complex fragrances.

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of cosmetic science

VOLUME: 25

Page Numbers: 235-43

Journal Abbreviation:

ISSN: 1467-2494

DAY: 22

MONTH: Oct

YEAR: 2003

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8007161

Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Two-stage kinetic analysis of fragrance evaporation and absorption from skin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Two-stage kinetic analysis of fragrance evaporation and absorption from skin.

AFFILIATION: College of Pharmacy, The University of Cincinnati Medical Center, Cincinnati, OH 45267-0004, U.S.A.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Cosmet Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Two-stage kinetic analysis of fragrance evaporation and absorption from skin Related Publications

• A critical role for central vasopressin in regulation of fever during bacterial infection.
• A geometrical model of dermal capillary clearance.
• Central vasopressin V1-blockade prevents salicylate but not acetaminophen antipyresis.
• Central vasopressin V1-receptors mediate indomethacin-induced antipyresis in rats.
• Centrally acting vasopressin contributes to endotoxin tolerance.
• Effect of hydration on the permeation of ketoconazole through human nail plate in vitro.
• Equilibrium water sorption characteristics of the human nail.
• Glucose partition coefficient and diffusivity in the lower skin layers.
• Partitioning, diffusivity and clearance of skin permeants in mammalian dermis.
• Permeation of tecnazene through human skin in vitro as assessed by HS-SPME and GC-MS.
• Session 22. Habitability of super-earths.
• Thermodynamics of water interaction with human stratum corneum I: measurement by isothermal calorimetry.
• Two-stage kinetic analysis of fragrance evaporation and absorption from skin.
• Unusual computed tomographic presentation of cerebral toxoplasmosis.
• Water diffusivity in human nail plate.