Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity.

Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity. Research Abstract Details 

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Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity. Abstract Text:

UiJoung Youn,Quan Cheng Chen,Ik Soo Lee,HongJin Kim,Jae-Kuk Yoo,JongPill Lee,Minkyun Na,Byung-Sun Min,KiHwan Bae,Uijoung Youn,Quan Cheng Chen,Ik Soo Lee,Hongjin Kim,Jae-Kuk Yoo,Jongpill Lee,Minkyun Na,Byung-Sun Min,Kihwan Bae,UiJoung Youn,Quan Cheng Chen,Ik Soo Lee,HongJin Kim,Jae-Kuk Yoo,JongPill Lee,Minkyun Na,Byung-Sun Min,KiHwan Bae,UiJoung Youn,Quan Cheng Chen,Ik Soo Lee,HongJin Kim,Jae-Kuk Yoo,JongPill Lee,Minkyun Na,Byung-Sun Min,KiHwan Bae,UiJoung Youn,Quan Cheng Chen,Ik Soo Lee,HongJin Kim,Jae-Kuk Yoo,JongPill Lee,Minkyun Na,Byung-Sun Min,KiHwan Bae,

Two new lignans, 4-methoxymagnaldehyde B (1) and coumanolignan (2), were isolated from the stem bark of Magnolia obovata, together with 11 known compounds (3-13). The structures of compounds 1 and 2 were determined to be 5'-allyl-2'-hydroxyphenyl-4-methoxy-3-cinnamic aldehyde (1) and 6-allyl-8-(5'-allyl-2'-hydroxyphenyl)coumarin (2) on the basis of spectroscopic and physicochemical analyses including 2D NMR and high-resolution EI-MS. Compounds 1-8, 11, 12, and 13 were tested in vitro for their cytotoxic activities against the HeLa, A549, and HCT116 cancer cell lines. Among the compounds tested, compound 1 showed the strongest cytotoxic activity against the HCT116 cancer cell line, with an IC(50) value of 1.3 mug/ml.

Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity. Publishing Authors By Initials

U Youn,QC Chen,IS Lee,H Kim,JK Yoo,J Lee,M Na,BS Min,K Bae,U Youn,QC Chen,IS Lee,H Kim,JK Yoo,J Lee,M Na,BS Min,K Bae,U Youn,QC Chen,IS Lee,H Kim,JK Yoo,J Lee,M Na,BS Min,K Bae,U Youn,QC Chen,IS Lee,H Kim,JK Yoo,J Lee,M Na,BS Min,K Bae,U Youn,QC Chen,IS Lee,H Kim,JK Yoo,J Lee,M Na,BS Min,K Bae,

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Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Chemical & pharmaceutical bulletin

VOLUME: 56

Page Numbers: 115-7

Journal Abbreviation: Chem. Pharm. Bull.

ISSN: 0009-2363

DAY: 7

MONTH: Jan

YEAR: 2008

Two New Lignans from the Stem Bark of Magnolia obovata and Their Cytotoxic Activity. Information

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LANGUAGE: eng

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AFFILIATION: College of Pharmacy, Chungnam National University.

Country: Japan

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MEDLINETA: Chem Pharm Bull (Tokyo)

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