Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation.

Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation. Research Abstract Details 

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Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation. Abstract Text:

Qing Lu,Li Zhang,Guo-Rong He,Heng-Xing Liang,Guan-Hua Du,Yong-Xian Cheng,Qing Lu,Li Zhang,Guo-Rong He,Heng-Xing Liang,Guan-Hua Du,Yong-Xian Cheng,

Two new alkaloids, brachystemidines F (1) and G (2), were isolated from the roots of Brachystemma calycinum. Their structures were established on the basis of detailed spectroscopic analyses, including extensive NMR and HR-MS techniques. Compound 2, which exhibits an unusual N-hydroxydiazenyl (HO-N=N) moiety, is a potent immunosuppressive agent, as demonstrated by inhibition of mouse T- and B-lymphocyte proliferation, with IC50 values of 6.33 and 5.60 microg/ml, resp.

Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation. Publishing Authors By Initials

Q Lu,L Zhang,GR He,HX Liang,GH Du,YX Cheng,Q Lu,L Zhang,GR He,HX Liang,GH Du,YX Cheng,

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Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Chemistry & biodiversity

VOLUME: 4

Page Numbers: 2948-52

Journal Abbreviation: Chem. Biodivers.

ISSN: 1612-1880

DAY: 20

MONTH: Dec

YEAR: 2007

Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Two new alkaloids from Brachystemma calycinum and their inhibitory effects on lymphocyte proliferation.

AFFILIATION: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, PR China.

Country: Switzerland

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MEDLINETA: Chem Biodivers

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