Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation.

Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Research Abstract Details 

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Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Abstract Text:

S Suzuki,K Mitani,K Kuwabara,Y Takahashi,O Niwa,R Kominami,

Pc-1 and Pc-2 hypervariable minisatellites of the mouse show a structural similarity and hence have been compared in terms of chromosomal location and mutability. Polymorphisms of the Pc-2 locus detected by analyses of Southern blotting and polymerase chain reaction were used for typing 61 backcross mice that were obtained by mating (C57BL/6 x MSM)F1 females to MSM males. Segregation patterns indicated that the Pc-2 locus maps to the 60 cM region of chromosome 6, while that of Pc-1 maps to chromosome 4. Simultaneous mutation of the two loci was examined in 101 F1 mice. Pc-1 and Pc-2 loci showed mutation rates of 14.4 and 5.0% per gamete, respectively. Of the nine mice with a Pc-2 mutation, four carried a Pc-1 mutation at the same maternally- or paternally-derived allele. The rate of comutation was 44% (4/9), higher than the 12.2% (24/197) of Pc-1 mutation alone. This suggests that the germline mutation of the two hypervariable minisatellites may result from a common mechanism.

Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Publishing Authors By Initials

S Suzuki,K Mitani,K Kuwabara,Y Takahashi,O Niwa,R Kominami,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 114

Page Numbers: 292-6

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1993

Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Information

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LANGUAGE: eng

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Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: genetics

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Substance Name: DNA, Satellite

Registry Number: 0

Grant and Affiliation Information for Two mouse hypervariable minisatellites: chromosomal location and simultaneous mutation.

AFFILIATION: First Department of Biochemistry, Niigata University School of Medicine.

Country: JAPAN

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MEDLINETA: J Biochem

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