Two molecular forms of adrenomedullin in congenital heart disease.

Two molecular forms of adrenomedullin in congenital heart disease. Research Abstract Details 

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Two molecular forms of adrenomedullin in congenital heart disease. Abstract Text:

K Watanabe,T Nishikimi,M Takamuro,K Yasuda,Y Ishikawa,S Tanabe,O Yamada,N Nagaya,H Matsuoka,K Kangawa,S Echigo,

To investigate the pathophysiological role of two forms of adrenomedullin (AM), a mature AM (AM-m) and a glycine-extended AM (AM-Gly), in congenital heart disease, we measured plasma levels of AM in patients with cyanotic heart disease, high pulmonary blood flow without pulmonary hypertension (PH), high pulmonary blood flow with PH, Fontan procedure, intracardiac repair without complication, and intracardiac repair with PH and control subjects. Plasma AM-m and AM-Gly were increased only for cyanotic heart disease (2.5 +/- 1.3 pmol/L, p < 0.001; 13.1 +/- 6.2 pmol/L, p < 0.05) and intracardiac repair with PH (2.3 +/- 1.5 pmol/L, p < 0.01; 13.0 +/- 7.0 pmol/L, p < 0.05) compared with control (1.0 +/- 1.4 and 8.6 +/- 1.3 pmol/L, respectively). They were similarly correlated with mean systemic arterial pressure (r = -0.40 and -0.37 respectively; p < 0.001), mixed venous oxygen saturation (r = -0.60 and -0.50; p < 0.0001), systemic arterial oxygen saturation (SA(sat)) (r = -0.56 and -0.46; p < 0.0001), and pulmonary arterial resistance (Rp) (r = 0.41 and 0.38; p < 0.005). Multiple regression analysis revealed that SA(sat) and Rp were independently correlated with AM. Interestingly, the venous AM-m level was significantly higher than the arterial AM-m, suggesting that the mature form is extracted in pulmonary circulation, whereas there were no venoarterial differences in AM-Gly. These results suggest that plasma AM-m and AM-Gly are similarly regulated and the main clearance site of AM-m is the lung in patients with congenital heart disease.

Two molecular forms of adrenomedullin in congenital heart disease. Publishing Authors By Initials

K Watanabe,T Nishikimi,M Takamuro,K Yasuda,Y Ishikawa,S Tanabe,O Yamada,N Nagaya,H Matsuoka,K Kangawa,S Echigo,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research

PUBMED ID PMID:

MEDLINE DATE: 2003 Nov-Dec

Two molecular forms of adrenomedullin in congenital heart disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric cardiology

VOLUME: 24

Page Numbers: 559-65

Journal Abbreviation: Pediatr Cardiol

ISSN: 0172-0643

DAY: 4

MONTH: 09

YEAR: 2003

Two molecular forms of adrenomedullin in congenital heart disease. Information

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LANGUAGE: eng

NlmUniqueID: 8003849

Two molecular forms of adrenomedullin in congenital heart disease. Keywords Mesh Terms:

KEYWORDS: Vascular Resistance

MESH TERMS: blood

Chemical & Substance for Abstract: Two molecular forms of adrenomedullin in congenital heart disease. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Two molecular forms of adrenomedullin in congenital heart disease.

AFFILIATION: Department of Pediatrics, National Cardiovascular Center, 5-7-1 Fujishirodai, Suita, Osaka 565-8565, Japan.

Country: United States

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MEDLINETA: Pediatr Cardiol

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