Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population.

Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Research Abstract Details 

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Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Abstract Text:

Rafael Moreno-Luna,Francisco Perez-Jimenez,Carmen Marin,Pablo Perez-Martinez,Purificacion Gomez,Yolanda Jimenez-Gomez,Javier Delgado-Lista,Juan A Moreno,Toshiko Tanaka,Jose M Ordovas,Jose Lopez-Miranda,

BACKGROUND: Apolipoprotein A5 (APOA5) plays an important role in plasma triacylglycerol (TG) homeostasis. Five polymorphisms (1131T>C, c.-3A>G, c.56C>G, IVS3+476G>A, and c.1259T>C) in the APOA5 gene define three common haplotypes (APOA5*1, APOA5*2, and APOA5*3) in Caucasian individuals. Our aim was to determine whether these haplotypes could modulate the postprandial response in young healthy males. DESIGN AND METHODS: Eighty-eight APO E3/3 volunteers [67 with (-1131T and 56C) APOA5*1 haplotype, 12 with (-1131C and 56C) APOA5*2 haplotype, and nine with (-1131T and 56G) APOA5*3 haplotype] underwent a fat load test consisting of the consumption of 1 g of fat per kilogram body weight and 60,000 IU vitamin A. Blood samples were taken at time 0, at every hour until the sixth hour, and at every 2.5 h until the 11th hour. Total plasma cholesterol (C) and TG, and C, TG, apolipoprotein B-100, apolipoprotein B-48, and retinyl palmitate in lipoprotein fractions were determined. RESULTS: Subjects with the APOA5*2 and APOA5*3 haplotypes had a higher area under the curve of total plasma TG (P = 0.03), large TG-rich lipoprotein (TRL)-TG (P = 0.02), small TRL-TG (P = 0.04), small TRL-C (P = 0.04), large TRL-C (P = 0.03), and small apolipoprotein B100 (P = 0.04) than subjects with the APOA5*1 haplotype. CONCLUSIONS: Our findings show that the presence of the APOA5*2 and APOA5*3 haplotypes in the APOA5 gene is associated with a higher postprandial response that could be involved in the higher risk of coronary heart disease associated with the 56G and -1131C alleles.

Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Publishing Authors By Initials

R Moreno-Luna,F Perez-Jimenez,C Marin,P Perez-Martinez,P Gomez,Y Jimenez-Gomez,J Delgado-Lista,JA Moreno,T Tanaka,JM Ordovas,J Lopez-Miranda,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 92

Page Numbers: 2280-5

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 13

MONTH: 03

YEAR: 2007

Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Information

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LANGUAGE: eng

NlmUniqueID: 375362

Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: blood

Chemical & Substance for Abstract: Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population. Information

Substance Name: Triglycerides

Registry Number: 0

Grant and Affiliation Information for Two independent apolipoprotein A5 haplotypes modulate postprandial lipoprotein metabolism in a healthy Caucasian population.

AFFILIATION: Unit of Lipids and Atherosclerosis, Hospital Universitario Reina Sofía, Avda Menéndez Pidal, Córdoba, Spain.

Country: United States

AGENCY: United States NHLBI

GRANT: HL54776

ACRONYM: HL

MEDLINETA: J Clin Endocrinol Metab

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