Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation.

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Research Abstract Details 

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Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Abstract Text:

Barrero,Sohail Malik,

Nuclear receptors, like other transcriptional activators, switch on gene transcription by recruiting a complex network of coregulatory proteins. Here, we have identified the arginine methyltransferase PRMT1 as a coactivator for HNF4, an orphan nuclear receptor that regulates the expression of genes involved in diverse metabolic pathways. Remarkably, PRMT1, whose methylation activity on histone H4 strongly correlates with induction of HNF4 target genes in differentiating enterocytes, regulates HNF4 activity through a bipartite mechanism. First, PRMT1 binds and methylates the HNF4 DNA-binding domain (DBD), thereby enhancing the affinity of HNF4 for its binding site. Second, PRMT1 is recruited to the HNF4 ligand-binding domain (LBD) through a mechanism that involves the p160 family of coactivators and methylates histone H4 at arginine 3. This, together with recruitment of the histone acetyltransferase p300, leads to nucleosomal alterations and subsequent RNA polymerase II preinitiation complex formation.

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Publishing Authors By Initials

MJ Barrero,S Malik,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Molecular cell

VOLUME: 24

Page Numbers: 233-43

Journal Abbreviation: Mol. Cell

ISSN: 1097-2765

DAY: 20

MONTH: Oct

YEAR: 2006

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9802571

Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: physiology

Chemical & Substance for Abstract: Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation. Information

Substance Name: Protein-Arginine N-Methyltransferase

Registry Number: EC 2.1.1.23

Grant and Affiliation Information for Two functional modes of a nuclear receptor-recruited arginine methyltransferase in transcriptional activation.

AFFILIATION: Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK060764

ACRONYM: DK

MEDLINETA: Mol Cell

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