Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents.

Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Research Abstract Details 

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Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Abstract Text:

Chang-Hoon Cho,Fannie St-Gelais,Wei Zhang,Susumu Tomita,James R Howe,

Transmembrane AMPA receptor regulatory proteins (TARPs) are auxiliary AMPA receptor subunits that regulate both the trafficking and gating properties of AMPA receptors, and different TARP isoforms display distinct expression patterns in brain. Here, we compared the effects of four TARP isoforms on the kinetics of AMPA receptor currents. Each isoform slowed the deactivation of GluR1 currents, but the slowing was greatest with gamma-4 and gamma-8. Isoform-specific differences in desensitization were also observed that correlated with effects on deactivation. TARP isoforms also differentially modulated responses to trains of glutamate applications designed to mimic high-frequency presynaptic firing. Importantly, whereas both stargazin and gamma-4 rescued excitatory synaptic transmission in cerebellar granule cells from stargazer mice, the decay of miniature EPSCs was 2-fold slower in neurons expressing gamma-4. The results show that heterogeneity in the composition of AMPA receptor/TARP complexes contributes to synapse-specific differences in EPSC decays and frequency-dependent modulation of neurotransmission.

Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Publishing Authors By Initials

CH Cho,F St-Gelais,W Zhang,S Tomita,JR Howe,

For similar synaptic transmission research abstracts see: synaptic transmission research

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Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuron

VOLUME: 55

Page Numbers: 890-904

Journal Abbreviation: Neuron

ISSN: 0896-6273

DAY: 20

MONTH: Sep

YEAR: 2007

Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8809320

Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Keywords Mesh Terms:

KEYWORDS: Synaptic Transmission

MESH TERMS: physiology

Chemical & Substance for Abstract: Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents. Information

Substance Name: glutamate receptor ionotropic, AMPA 1

Registry Number: 0

Grant and Affiliation Information for Two families of TARP isoforms that have distinct effects on the kinetic properties of AMPA receptors and synaptic currents.

AFFILIATION: Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USA.

Country: United States

AGENCY: United States NINDS

GRANT: NS-047712

ACRONYM: NS

MEDLINETA: Neuron

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