Two circadian oscillatory mechanisms in the mammalian retina.

Two circadian oscillatory mechanisms in the mammalian retina. Research Abstract Details 

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Two circadian oscillatory mechanisms in the mammalian retina. Abstract Text:

K Sakamoto,K Oishi,M Shiraishi,S Hamano,H Otsuka,Y Miyake,N Ishida,

To investigate the mechanism that controls circadian rhythms in the mammalian retina, we examined the mRNA expression rhythms of serotonin N-acetyltransferase (NAT), the mammalian clock gene rPer2 and a clock-controlled gene Dbp in the retina of rats with lesions of the suprachiasmatic nucleus (SCN), the master clock in mammals. Northern blot analyses showed that retinal NAT mRNA still exhibited the circadian expression in the SCN-lesioned rats, whereas the lesion abolished the rhythms of rPer2 and Dbp mRNAs. These findings suggest that the mammalian retina has two circadian oscillatory mechanisms: one can generate rhythmicity independent of the SCN and the other requires the SCN to maintain circadian oscillation.

Two circadian oscillatory mechanisms in the mammalian retina. Publishing Authors By Initials

K Sakamoto,K Oishi,M Shiraishi,S Hamano,H Otsuka,Y Miyake,N Ishida,

For similar proteins: transcription factors research abstracts see: proteins: transcription factors research

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Two circadian oscillatory mechanisms in the mammalian retina. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuroreport

VOLUME: 11

Page Numbers: 3995-7

Journal Abbreviation: Neuroreport

ISSN: 0959-4965

DAY: 18

MONTH: Dec

YEAR: 2000

Two circadian oscillatory mechanisms in the mammalian retina. Information

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LANGUAGE: eng

NlmUniqueID: 9100935

Two circadian oscillatory mechanisms in the mammalian retina. Keywords Mesh Terms:

KEYWORDS: Transcription Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: Two circadian oscillatory mechanisms in the mammalian retina. Information

Substance Name: Arylamine N-Acetyltransferase

Registry Number: EC 2.3.1.5

Grant and Affiliation Information for Two circadian oscillatory mechanisms in the mammalian retina.

AFFILIATION: Ishida Group of Clock Gene, National Institute of Bioscience and Human Technology, Agency of Industrial Science and Technology, MITI, Tsukuba, Japan.

Country: England

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MEDLINETA: Neuroreport

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