Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs.

Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs. Research Abstract Details 

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Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs. Abstract Text:

Junying Xu,Robert A Ross,Richard W McCallum,Jiande D Z Chen,Junying Xu,Robert A Ross,Richard W McCallum,Jiande D Z Chen,Junying Xu,Robert A Ross,Richard W McCallum,Jiande D Z Chen,

BACKGROUND: The aim of the current study was to investigate the efficacy of 2-channel gastric electrical stimulation (GES) with a custom-made implantable pacemaker on delayed gastric emptying and gastric dysryhthmia induced by glucagon in dogs. METHODS: Six dogs were studied in 4 randomized session (saline, glucagon, glucagon with single-channel or 2-channel GES). GES was applied via the first pair of electrodes for single-channel GES or the first and third pairs of electrodes for 2-channel GES. Gastric emptying was assessed for 90 minutes and gastric slow waves were recorded at the same time. RESULTS: Both single-channel and 2-channel GES improved gastric dysryhthmia (P < .05 vs glucagon session). Two-channel GES but not single-channel GES improved glucagon-induced delayed gastric emptying at 30 minutes, 45 minutes, 60 minutes, 75 minutes, and 90 minutes. CONCLUSION: Two-channel GES with a novel implantable pacemaker is more efficient and effective than single-channel GES in improving delayed gastric emptying induced by glucagon. This implantable multipoint pacemaker may provide a new option for treatment of gastric motility disorders.

Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs. Publishing Authors By Initials

J Xu,RA Ross,RW McCallum,JD Chen,J Xu,RA Ross,RW McCallum,JD Chen,J Xu,RA Ross,RW McCallum,JD Chen,

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Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of surgery

VOLUME: 195

Page Numbers: 122-9

Journal Abbreviation: Am. J. Surg.

ISSN: 0002-9610

DAY: 17

MONTH: Jan

YEAR: 2008

Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Two-channel gastric pacing with a novel implantable gastric pacemaker accelerates glucagon-induced delayed gastric emptying in dogs.

AFFILIATION: Division of Gastroenterology, University of Texas Medical Branch, Galveston, TX, USA.

Country: United States

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MEDLINETA: Am J Surg

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