Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator.

Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Research Abstract Details 

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Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Abstract Text:

Anne Petitjean,Jacqueline K Barton,

A novel bimetallic conjugate combining a rhodium intercalator that selectively binds DNA mismatches and a reactive cis-platinum analogue that targets DNA by coordination has been prepared. The site-selectivity of the bimetallic complex in forming coordination adducts is examined using mismatched and well-matched oligonucleotides of different sequences. The results indicate that through the bifunctional complex, the platinum center can be targeted near mismatched sites. Interestingly, with mismatched, DNA both intrastrand and the less common interstrand cross-linked adducts are formed. The recognition of a DNA mismatch by the bulky Rh intercalator appears to direct the Pt unit, depending upon steric contraints, to react preferentially with mismatched DNA at a site that may or may not be the preferred site of Pt coordination. Thus, the presence of a permanent link to a site-specific intercalator is able to tune the reactivity of the cis-platinum analogue.

Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Publishing Authors By Initials

A Petitjean,JK Barton,

For similar organic chemicals: organometallic compounds research abstracts see: organic chemicals: organometallic compounds research

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Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 14728-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 17

MONTH: Nov

YEAR: 2004

Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Keywords Mesh Terms:

KEYWORDS: Organometallic Compounds

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for Tuning the DNA reactivity of cis-platinum: conjugation to a mismatch-specific metallointercalator.

AFFILIATION: Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 33309

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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